Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations

doi:10.1371/journal.pone.0267916

KMS > iHuman研究所 > PI研究组 > Garth John Thompson组

	Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations
	Sanganahalli, Basavaraju G.1,2; Thompson, Garth J.1,2,3 ; Parent, Maxime 1,2; Verhagen, Justus V.4,5; Blumenfeld, Hal 5,6,7; Herman, Peter 1,2; Hyder, Fahmeed 1,2,8
	2022
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	17 期号:5
发表状态	已发表
DOI	10.1371/journal.pone.0267916
摘要	The thalamus is a crucial subcortical hub that impacts cortical activity. Tracing experiments in animals and post-mortem humans suggest rich morphological specificity of the thalamus. Very few studies reported rodent thalamic activations by functional MRI (fMRI) as compared to cortical activations for different sensory stimuli. Here, we show different portions of the rat thalamus in response to tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimuli with high field fMRI (11.7T) using a custom-build quadrature surface coil to capture high sensitivity signals from superficial and deep brain regions simultaneously. Results demonstrate reproducible thalamic activations during both tactile and non-tactile stimuli. Forepaw and whisker stimuli activated broader regions within the thalamus: ventral posterior lateral (VPL), ventral posterior medial (VPM), lateral posterior mediorostral (LPMR) and posterior medial (POm) thalamic nuclei. Visual stimuli activated dorsal lateral geniculate nucleus (DLG) of the thalamus but also parts of the superior/inferior colliculus, whereas olfactory stimuli activated specifically the mediodorsal nucleus of the thalamus (MDT). BOLD activations in LGN and MDT were much stronger than in VPL, VPM, LPMR and POm. These fMRI-based thalamic activations suggest that forepaw and whisker (i.e., tactile) stimuli engage VPL, VPM, LPMR and POm whereas visual and olfactory (i.e., non-tactile) stimuli, respectively, recruit DLG and MDT exclusively.
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Institutes of Health["R01 MH-067528","NS-052519","2T32DA-022975-06A1"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000835222600041
出版者	PUBLIC LIBRARY SCIENCE
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214769
专题	iHuman研究所_PI研究组_Garth John Thompson组
通讯作者	Sanganahalli, Basavaraju G.; Hyder, Fahmeed
作者单位	1.Yale Univ, Magnet Resonance Res Ctr MRRC, New Haven, CT 06520 USA 2.Yale Univ, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA 3.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 4.John B Pierce Lab, New Haven, CT USA 5.Yale Univ, Dept Neurosci, New Haven, CT USA 6.Yale Univ, Dept Neurol, New Haven, CT USA 7.Yale Univ, Dept Neurosurg, New Haven, CT USA 8.Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA
推荐引用方式 GB/T 7714	Sanganahalli, Basavaraju G.,Thompson, Garth J.,Parent, Maxime,et al. Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations[J]. PLOS ONE,2022,17(5).
APA	Sanganahalli, Basavaraju G..,Thompson, Garth J..,Parent, Maxime.,Verhagen, Justus V..,Blumenfeld, Hal.,...&Hyder, Fahmeed.(2022).Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations.PLOS ONE,17(5).
MLA	Sanganahalli, Basavaraju G.,et al."Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations".PLOS ONE 17.5(2022).