Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents
Guo, Ao1,4; He, Dongming4,5; Xu, Hong-Bo3; Geng, Chang-An3; Zhao, Jian2,4
2015-09-15
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5
Status已发表
DOI10.1038/srep14046
Abstract

Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases.

Indexed BySCI
Language英语
Funding ProjectShanghai Municipal Commission for Science and Technology[14DZ1900402]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000361180900001
PublisherNATURE PUBLISHING GROUP
WOS KeywordISOLIQUIRITIGENIN ; DIFFERENTIATION ; REG ; AKT ; GLYCYRRHIZIN ; ACTIVATION ; EXPRESSION ; INHIBITOR ; APOPTOSIS ; FOXP3
Original Document TypeArticle
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2135
Collection生命科学与技术学院
生命科学与技术学院_硕士生
免疫化学研究所_PI研究组_赵简组
Corresponding AuthorZhao, Jian
Affiliation1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
2.Tongji Univ, Sch Med, Shanghai East Hosp, Translat Med Ctr Stem Cell Therapy, Shanghai 200120, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
Recommended Citation
GB/T 7714
Guo, Ao,He, Dongming,Xu, Hong-Bo,et al. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents[J]. SCIENTIFIC REPORTS,2015,5.
APA Guo, Ao,He, Dongming,Xu, Hong-Bo,Geng, Chang-An,&Zhao, Jian.(2015).Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.SCIENTIFIC REPORTS,5.
MLA Guo, Ao,et al."Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents".SCIENTIFIC REPORTS 5(2015).
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