ShanghaiTech University Knowledge Management System
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents | |
Guo, Ao1,4; He, Dongming4,5; Xu, Hong-Bo3; Geng, Chang-An3; Zhao, Jian2,4 | |
2015-09-15 | |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 5 |
发表状态 | 已发表 |
DOI | 10.1038/srep14046 |
摘要 | Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Shanghai Municipal Commission for Science and Technology[14DZ1900402] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000361180900001 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | ISOLIQUIRITIGENIN ; DIFFERENTIATION ; REG ; AKT ; GLYCYRRHIZIN ; ACTIVATION ; EXPRESSION ; INHIBITOR ; APOPTOSIS ; FOXP3 |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2135 |
专题 | 生命科学与技术学院 生命科学与技术学院_硕士生 免疫化学研究所_PI研究组_赵简组 |
通讯作者 | Zhao, Jian |
作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 2.Tongji Univ, Sch Med, Shanghai East Hosp, Translat Med Ctr Stem Cell Therapy, Shanghai 200120, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
推荐引用方式 GB/T 7714 | Guo, Ao,He, Dongming,Xu, Hong-Bo,et al. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents[J]. SCIENTIFIC REPORTS,2015,5. |
APA | Guo, Ao,He, Dongming,Xu, Hong-Bo,Geng, Chang-An,&Zhao, Jian.(2015).Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.SCIENTIFIC REPORTS,5. |
MLA | Guo, Ao,et al."Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents".SCIENTIFIC REPORTS 5(2015). |
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