Dissecting the genetic structure and admixture of four geographical Malay populations

doi:10.1038/srep14375

	Dissecting the genetic structure and admixture of four geographical Malay populations
	Deng, Lian 1; Hoh, Boon-Peng 1,2; Lu, Dongsheng 1; Saw, Woei-Yuh 3,4; Ong, Rick Twee-Hee 3; Kasturiratne, Anuradhani 5; de Silva, H. Janaka 6; Zilfalil, Bin Alwi 7; Kato, Norihiro 8; Wickremasinghe, Ananda R.5; Teo, Yik-Ying 3,4,9,10,11; Xu, Shuhua1,12,13
	2015-09-23
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5
发表状态	已发表
DOI	10.1038/srep14375
摘要	The Malay people are an important ethnic composition in Southeast Asia, but their genetic make-up and population structure remain poorly studied. Here we conducted a genome-wide study of four geographical Malay populations: Peninsular Malaysian Malay (PMM), Singaporean Malay (SGM), Indonesian Malay (IDM) and Sri Lankan Malay (SLM). All the four Malay populations showed substantial admixture with multiple ancestries. We identified four major ancestral components in Malay populations: Austronesian (17%-62%), Proto-Malay (15%-31%), East Asian (4%-16%) and South Asian (3%-34%). Approximately 34% of the genetic makeup of SLM is of South Asian ancestry, resulting in its distinct genetic pattern compared with the other three Malay populations. Besides, substantial differentiation was observed between the Malay populations from the north and the south, and between those from the west and the east. In summary, this study revealed that the genetic identity of the Malays comprises a mixed entity of multiple ancestries represented by Austronesian, Proto-Malay, East Asian and South Asian, with most of the admixture events estimated to have occurred 175 to 1,500 years ago, which in turn suggests that geographical isolation and independent admixture have significantly shaped the genetic architectures and the diversity of the Malay populations.
收录类别	SCI
语种	英语
资助项目	National Science Foundation of China (NSFC)[91331204] ; National Science Foundation of China (NSFC)[31171218]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000361595800003
出版者	NATURE PUBLISHING GROUP
WOS关键词	HUMAN GENOME ; MAP ; INDIVIDUALS ; ASSOCIATION ; PHENOTYPE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2133
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, Max Planck Independent Res Grp Populat Genom,CAS, Shanghai 200031, Peoples R China 2.UCSI Univ, Fac Med & Hlth Sci, Kuala Lumpur 56000, Malaysia 3.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore 4.Natl Univ Singapore, Life Sci Inst, Singapore 117548, Singapore 5.Univ Kelaniya, Dept Publ Hlth, Fac Med, Ragama 11010, Sri Lanka 6.Univ Kelaniya, Fac Med, Dept Med, Ragama 11010, Sri Lanka 7.Univ Sains Malaysia, Sch Med Sci, Dept Pediat, Kelantan 16150, Malaysia 8.Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan 9.Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117548, Singapore 10.Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore 11.Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117548, Singapore 12.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 13.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Deng, Lian,Hoh, Boon-Peng,Lu, Dongsheng,et al. Dissecting the genetic structure and admixture of four geographical Malay populations[J]. SCIENTIFIC REPORTS,2015,5.
APA	Deng, Lian.,Hoh, Boon-Peng.,Lu, Dongsheng.,Saw, Woei-Yuh.,Ong, Rick Twee-Hee.,...&Xu, Shuhua.(2015).Dissecting the genetic structure and admixture of four geographical Malay populations.SCIENTIFIC REPORTS,5.
MLA	Deng, Lian,et al."Dissecting the genetic structure and admixture of four geographical Malay populations".SCIENTIFIC REPORTS 5(2015).