Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity

doi:10.1007/s00438-015-1032-8

	Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity
	Jha, Pankaj 1; Lu, Dongsheng 1; Yuan, Yuan 1; Xu, Shuhua1,2,3
	2015-10
发表期刊	MOLECULAR GENETICS AND GENOMICS (IF:2.3[JCR-2023],2.5[5-Year])
ISSN	1617-4615
卷号	290 期号:5 页码:1741-1752
发表状态	已发表
DOI	10.1007/s00438-015-1032-8
摘要	Analysis of natural selection events is an attractive strategy for identification of functional variants shaped by gene-environmental interactions and human adaptation. Here, we identified PTK6, a Src-related tyrosine kinase gene, underlying positive selection in East Asian populations. Interestingly, PTK6 variant showed significant correlation with gastric cancer incidences which was the highest in East Asian populations. The high prevalence of gastric cancer in East Asians was also believed to be strongly affected by Helicobacter pylori infection and dietary habit. Therefore, we speculated a competitive interaction of cancer-associated molecules for activation/reduction, where PTK6 likely plays a role through CagA-driven signaling pathway after H. pylori infection. This hypothesis was also supported by our gene expression analysis and the dating of the selective event which was estimated to be similar to 16,500 years ago, much later than H. pylori invasion in human 50,000 years ago. Establishment of cross talk between PTK6 and CagA by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer.
关键词	PTK6 Natural selection East Asian H. pylori Gastric cancer
收录类别	SCI
语种	英语
资助项目	International Young Scientist Fellowship of Chinese Academy of Sciences[2011Y2SB10]
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000361555200008
出版者	SPRINGER HEIDELBERG
WOS关键词	TYROSINE KINASE GENE ; NATURAL-SELECTION ; LINKAGE DISEQUILIBRIUM ; MODERN HUMANS ; BETA-CATENIN ; HUMAN GENOME ; EXPRESSION ; BRK ; ACTIVATION ; FOOTPRINTS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2128
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CASMPG Partner Inst Computat Biol PICB, Key Lab Computat Biol,Max Planck Independent Res, Shanghai 200031, Peoples R China 2.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Jha, Pankaj,Lu, Dongsheng,Yuan, Yuan,et al. Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity[J]. MOLECULAR GENETICS AND GENOMICS,2015,290(5):1741-1752.
APA	Jha, Pankaj,Lu, Dongsheng,Yuan, Yuan,&Xu, Shuhua.(2015).Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity.MOLECULAR GENETICS AND GENOMICS,290(5),1741-1752.
MLA	Jha, Pankaj,et al."Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity".MOLECULAR GENETICS AND GENOMICS 290.5(2015):1741-1752.