Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles

doi:10.1093/jmcb/mjv019

	Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles
	Liu, Hui 1,2; Wu, Qing-Feng 1,2; Li, Jia-Yin 1,2; Liu, Xing-Jun 1,2; Li, Kai-Cheng 1,2; Zhong, Yan-Qing 1,2; Wu, Dan 1,2; Wang, Qiong 3; Lu, Yin-Jing 1,2; Bao, Lan3,4 ; Zhang, Xu1,2,4
	2015-10
发表期刊	JOURNAL OF MOLECULAR CELL BIOLOGY
ISSN	1674-2788
卷号	7 期号:5 页码:466-475
发表状态	已发表
DOI	10.1093/jmcb/mjv019
摘要	Fibroblast growth factor (FGF) 7, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. However, its functions in the nervous system are largely unknown. The present study showed that FGF7 was a neuromodulator localized in the large dense-core vesicles (LDCVs) in nociceptive neurons. FGF7 was mainly expressed in small-diameter neurons of the dorsal root ganglion and could be transported to the dorsal spinal cord. Interestingly, FGF7 was mostly stored in LDCVs that did not contain neuropeptide substance P. Electrophysiological recordings in the spinal cord slice showed that buffer-applied FGF7 increased the amplitude of excitatory post-synaptic current evoked by stimulating the sensory afferent fibers. Behavior tests showed that intra-thecally applied FGF7 potentiated the formalin-induced acute nociceptive response. Moreover, both acute and inflammatory nociceptive responses were significantly reduced in Fgf7-deficient mice. These results suggest that FGF7 exerts an excitatory modulation of nociceptive afferent transmission.
关键词	fibroblast growth factor 7 dorsal root ganglion large dense-core vesicle nociceptive modulator inflammatory pain
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program (B) of Chinese Academy of Sciences[XDB01020300]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000363201800008
出版者	OXFORD UNIV PRESS
WOS关键词	SUBSTANTIA-GELATINOSA NEURONS ; DELTA-OPIOID RECEPTOR ; DORSAL-ROOT GANGLION ; RAT SPINAL-CORD ; AFFERENT GLUTAMATERGIC TRANSMISSION ; NEUROPATHIC PAIN ; SENSORY NEURONS ; INFLAMMATORY PAIN ; UP-REGULATION ; IN-VITRO
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2124
专题	生命科学与技术学院_特聘教授组_鲍岚组生命科学与技术学院_特聘教授组_张旭组
通讯作者	Zhang, Xu
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Hui,Wu, Qing-Feng,Li, Jia-Yin,et al. Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(5):466-475.
APA	Liu, Hui.,Wu, Qing-Feng.,Li, Jia-Yin.,Liu, Xing-Jun.,Li, Kai-Cheng.,...&Zhang, Xu.(2015).Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles.JOURNAL OF MOLECULAR CELL BIOLOGY,7(5),466-475.
MLA	Liu, Hui,et al."Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles".JOURNAL OF MOLECULAR CELL BIOLOGY 7.5(2015):466-475.