Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo

doi:10.1021/acs.nanolett.8b00087

	Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo
	Zhang, Jing 1,2,3,4; Liu, Xiaojun 1,4; Xu, Wenjing 5; Luo, Wenhan 2,3,7; Li, Ming 2,3,6; Chu, Fangbing 1,4; Xu, Lu 5; Cao, Anyuan 5; Guan, Jisong7,8 ; Tang, Shiming 2,3,6; Duan, Xiaojie 1,3,4
	2018-05
发表期刊	NANO LETTERS
ISSN	1530-6984
卷号	18 期号:5 页码:2903-2911
发表状态	已发表
DOI	10.1021/acs.nanolett.8b00087
摘要	Recent developments of transparent electrode arrays provide a unique capability for simultaneous optical and electrical interrogation of neural circuits in the brain. However, none of these electrode arrays possess the stretchability highly desired for interfacing with mechanically active neural systems, such as the brain under injury, the spinal cord, and the peripheral nervous system (PNS). Here, we report a stretchable transparent electrode array from carbon nanotube (CNT) web-like thin films that retains excellent electrochemical performance and broad-band optical transparency under stretching and is highly durable under cyclic stretching deformation. We show that the CNT electrodes record well-defined neuronal response signals with negligible light-induced artifacts from cortical surfaces under optogenetic stimulation. Simultaneous two-photon calcium imaging through the transparent CNT electrodes from cortical surfaces of GCaMP-expressing mice with epilepsy shows individual activated neurons in brain regions from which the concurrent electrical recording is taken, thus providing complementary cellular information in addition to the high-temporal-resolution electrical recording. Notably, the studies on rats show that the CNT electrodes remain operational during and after brain contusion that involves the rapid deformation of both the electrode array and brain tissue. This enables real-time, continuous electrophysiological monitoring of cortical activity under traumatic brain injury. These results highlight the potential application of the stretchable transparent CNT electrode arrays in combining electrical and optical modalities to study neural circuits, especially under mechanically active conditions, which could potentially provide important new insights into the local circuit dynamics of the spinal cord and PNS as well as the mechanism underlying traumatic injuries of the nervous system.
关键词	Stretchable electronics transparent electrode neural electrode array brain activity mapping optogenetics calcium imaging traumatic brain injury nanobio interface carbon nanotube
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Basic Research Program of China[2016YFA0200103] ; National Basic Research Program of China[2014CB932500]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000432093200023
出版者	AMER CHEMICAL SOC
EI入藏号	20182005190567
EI主题词	Brain mapping ; Carbon films ; Carbon nanotubes ; Deformation ; Electric network analysis ; Electrochemical electrodes ; Electrophysiology ; Neurons ; Radiology ; Stretching ; Timing circuits ; Transparent electrodes ; Yarn
EI分类号	Bioengineering and Biology:461 ; Metal Forming:535.2 ; Electric Network Analysis:703.1.1 ; Pulse Circuits:713.4 ; Nanotechnology:761 ; Coating Materials:813.2 ; Fiber Products:819.4
WOS关键词	WALLED CARBON NANOTUBES ; LARGE-AREA ; BRAIN ; OPTOGENETICS ; GRAPHENE ; NEURONS ; ACCELERATION ; BIOMECHANICS ; DEFORMATION ; STIMULATION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20895
专题	生命科学与技术学院_PI研究组_管吉松组
通讯作者	Duan, Xiaojie
作者单位	1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 4.Peking Univ, Ctr Nanochem, Beijing Sci & Engn Ctr Nanocarbons, Beijing 100871, Peoples R China 5.Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China 6.Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China 7.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jing,Liu, Xiaojun,Xu, Wenjing,et al. Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo[J]. NANO LETTERS,2018,18(5):2903-2911.
APA	Zhang, Jing.,Liu, Xiaojun.,Xu, Wenjing.,Luo, Wenhan.,Li, Ming.,...&Duan, Xiaojie.(2018).Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.NANO LETTERS,18(5),2903-2911.
MLA	Zhang, Jing,et al."Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo".NANO LETTERS 18.5(2018):2903-2911.