The Progress of Cell Cycle Cdk1 Inhibitors in Budding Yeast

doi:10.16476/j.pibb.2017.0432

KMS > 免疫化学研究所 > 特聘教授组 > Richard A. Lerner组

	The Progress of Cell Cycle Cdk1 Inhibitors in Budding Yeast
	Liu Xue-Qin 1; Ren Ping2 ; Zhang Ze 1; Zeng Fan-Li 1
	2018-05
发表期刊	生物化学与生物物理进展 (IF:0.2[JCR-2023],0.3[5-Year])
ISSN	1000-3282
卷号	45 期号:5 页码:512-518
发表状态	已发表
DOI	10.16476/j.pibb.2017.0432
摘要	Cyclin-dependent kinase Cdk1 is the master regulator on eukaryotic cell cycle control and crucial for prevention of genomic instability. Given its essential function in cell cycle progression, Cdk1 is tightly regulated. Among others, CDK inhibitors (CKIs) are important negative factors for CDK activity regulation, lack of which leads to uncontrolled cell division and promotes tumorigenesis. The model eukaryotic organism Saccharomyces cerevisiae, budding yeast, in many respects is an ideal organism for eukaryotic CDK regulation research. In budding yeast three Cdk1 inhibitors are known: Far1, Sic1 and recently identified Cip1. Apart from inhibiting Cdk1 activity during cell cycle progression, CKIs also play crucial roles to maintain genomic stability in response to environmental stresses. This paper reviewed the researches on Cdk1 inhibitors, especially their functions on cell cycle progression and stress responses, to provide a model basis for cell cycle and cancer fundamental research.
关键词	budding yeast cell cycle Cdk1 CKI Cip1
收录类别	SCI ; SCIE ; 北大核心 ; CSCD
语种	中文
资助项目	Hebei Agricultural University[ZD201622]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000433010900004
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS关键词	DNA-DAMAGE CHECKPOINT ; CDC2 PROTEIN-KINASE ; D-DEPENDENT KINASES ; SACCHAROMYCES-CEREVISIAE ; TYROSINE PHOSPHORYLATION ; FISSION YEAST ; ACTIVATING KINASE ; G1 PHASE ; MULTISITE PHOSPHORYLATION ; GENETIC-CONTROL
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20881
专题	免疫化学研究所_特聘教授组_抗体设计学实验室
通讯作者	Zeng Fan-Li
作者单位	1.Hebei Agr Univ, Coll Life Sci, Banding 071001, Hebei, Peoples R China 2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Liu Xue-Qin,Ren Ping,Zhang Ze,et al. The Progress of Cell Cycle Cdk1 Inhibitors in Budding Yeast[J]. 生物化学与生物物理进展,2018,45(5):512-518.
APA	Liu Xue-Qin,Ren Ping,Zhang Ze,&Zeng Fan-Li.(2018).The Progress of Cell Cycle Cdk1 Inhibitors in Budding Yeast.生物化学与生物物理进展,45(5),512-518.
MLA	Liu Xue-Qin,et al."The Progress of Cell Cycle Cdk1 Inhibitors in Budding Yeast".生物化学与生物物理进展 45.5(2018):512-518.