Coding Cell Micropatterns Through Peptide Inkjet Printing for Arbitrary Biomineralized Architectures

doi:10.1002/adfm.201800228

	Coding Cell Micropatterns Through Peptide Inkjet Printing for Arbitrary Biomineralized Architectures
	Guo, Jin 1,2; Ling, Shengjie1,3,4 ; Li, Wenyi 1; Chen, Ying 1; Li, Chunmei 1; Omenetto, Fiorenzo G.1; Kaplan, David L.1
	2018-05-09
发表期刊	ADVANCED FUNCTIONAL MATERIALS (IF:18.5[JCR-2023],19.6[5-Year])
ISSN	1616-301X
卷号	28 期号:19
发表状态	已发表
DOI	10.1002/adfm.201800228
摘要	Well-designed micropatterns present in native tissues and organs involve changes in extracellular matrix compositions, cell types and mechanical properties to reflect complex biological functions. However, the design and fabrication of these micropatterns in vitro to meet task-specific biomedical applications remains a challenge. A de novo design strategy to code and synthesize functional micropatterns is presented to engineer cell alignment through the integration of aqueous-peptide inkjet printing and site-specific biomineralization. The inkjet printing provides direct writing of macroscopic biosilica selective peptide-R5 patterns with micrometer-scale resolution on the surface of a biopolymer (silk) hydrogel. This is combined with in situ biomineralization of the R5 peptide for site-specific growth of silica nanoparticles on the micropatterns, avoiding the use of harsh chemicals or complex processing. The functional micropatterned systems are used to align human mesenchymal stem cells and bovine serum albumin. This combination of peptide printing and site-specific biomineralization provides a new route for developing cost-effective micropatterns, with implications for broader materials designs.
关键词	biosilica cell alignment inkjet printing micropatterns site-specific biomineralization
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	ONR[N000141310596]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000431615300021
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	MESENCHYMAL STEM-CELLS ; NANOSTRUCTURED SILICA ; MECHANICAL-PROPERTIES ; SILK BIOMATERIALS ; IN-VITRO ; TISSUE ; MORPHOGENESIS ; DIATOMS ; TOOL ; MICROENVIRONMENTS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20880
专题	物质科学与技术学院_PI研究组_凌盛杰组
通讯作者	Omenetto, Fiorenzo G.; Kaplan, David L.
作者单位	1.Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA 2.Tufts Univ, Dept Chem & Biol Engn, Medford, MA 02155 USA 3.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 4.MIT, Dept Civil & Environm Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA
推荐引用方式 GB/T 7714	Guo, Jin,Ling, Shengjie,Li, Wenyi,et al. Coding Cell Micropatterns Through Peptide Inkjet Printing for Arbitrary Biomineralized Architectures[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(19).
APA	Guo, Jin.,Ling, Shengjie.,Li, Wenyi.,Chen, Ying.,Li, Chunmei.,...&Kaplan, David L..(2018).Coding Cell Micropatterns Through Peptide Inkjet Printing for Arbitrary Biomineralized Architectures.ADVANCED FUNCTIONAL MATERIALS,28(19).
MLA	Guo, Jin,et al."Coding Cell Micropatterns Through Peptide Inkjet Printing for Arbitrary Biomineralized Architectures".ADVANCED FUNCTIONAL MATERIALS 28.19(2018).