Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair

doi:10.1016/j.actbio.2018.02.033

	Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair
	Ma, Baojin 1; Han, Jing 2; Zhang, Shan 1; Liu, Feng 1; Wang, Shicai 1; Duan, Jiazhi 1; Sang, Yuanhua 1; Jiang, Huaidong4 ; Li, Dong 5; Ge, Shaohua 2; Yu, Jinghua 3; Liu, Hong 1,3
	2018-04-15
发表期刊	ACTA BIOMATERIALIA (IF:9.4[JCR-2023],9.9[5-Year])
ISSN	1742-7061
卷号	71 页码:108-117
发表状态	已发表
DOI	10.1016/j.actbio.2018.02.033
摘要	Controllable osteoinduction maintained in the original defect area is the key to precise bone repair. To meet the requirement of precise bone regeneration, a hydroxyapatite (HAp) nanobelt/polylactic acid (PLA) (HAp/PLA) Janus membrane has been successfully prepared in this study by coating PLA on a paper-like HAp nanobelt film by a casting-pervaporation method. The Janus membrane possesses dual functions: excellent osteoinduction from the hydrophilic HAp nanobelt side and barrier function originating from the hydrophobic PLA film. The cell viability and osteogenic differentiation ability of human adipose-derived stem cells (hADSCs) on the Janus membrane were assessed. The in vitro experimental results prove that the HAp nanobelt side presents high cell viability and efficient osteoinduction without any growth factor and that the PLA side can prohibit cell attachment. The in vivo repair experiments on a rat mandible defect model prove that the PLA side can prevent postoperative adhesion between bone and adjacent soft tissues. Most importantly, the HAp side has a strong ability to promote defect repair and bone regeneration. Therefore, the HAp/PLA Janus membrane will have wide applications as a kind of tissue engineering material in precise bone repair because of its unique dual osteoinduction/barrier functions, biocompatibility, low cost, and its ability to be mass-produced. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
关键词	HAp nanobelt HAp/PLA Janus membrane Osteoinduction/barrier Dual functions Precise bone defect repair
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Natural Science Foundation of China[81670993] ; National Natural Science Foundation of China[81371157]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000431470300009
出版者	ELSEVIER SCI LTD
WOS关键词	OSTEOGENIC DIFFERENTIATION ; INTRAABDOMINAL ADHESIONS ; MECHANICAL-PROPERTIES ; TISSUE REGENERATION ; DRUG-DELIVERY ; GROWTH-FACTOR ; BARRIER FILM ; STEM-CELLS ; COMPOSITES ; SCAFFOLDS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20876
专题	大科学中心_PI研究组_江怀东组物质科学与技术学院
通讯作者	Ge, Shaohua; Yu, Jinghua; Liu, Hong
作者单位	1.Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Shandong, Peoples R China 2.Shandong Univ, Sch Stomatol, Shandong Prov Key Lab Oral Tissue Regenerat, Jinan 250100, Shandong, Peoples R China 3.Univ Jinan, IAIR, Jinan 250022, Shandong, Peoples R China 4.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 5.Shandong Univ, Dept Pediat, Qilu Hosp, Jinan 250100, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Ma, Baojin,Han, Jing,Zhang, Shan,et al. Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair[J]. ACTA BIOMATERIALIA,2018,71:108-117.
APA	Ma, Baojin.,Han, Jing.,Zhang, Shan.,Liu, Feng.,Wang, Shicai.,...&Liu, Hong.(2018).Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair.ACTA BIOMATERIALIA,71,108-117.
MLA	Ma, Baojin,et al."Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair".ACTA BIOMATERIALIA 71(2018):108-117.