ShanghaiTech University Knowledge Management System
A DNA-based system for selecting and displaying the combined result of two input variables | |
Liu, Huajie1,2,3,4; Wang, Jianbang1,2; Song, Shiping1,2; Fan, Chunhai1,2,5; Gothelf, Kurt V.3,4 | |
2015-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 6 |
发表状态 | 已发表 |
DOI | 10.1038/ncomms10089 |
摘要 | Oligonucleotide-based technologies for biosensing or bio-regulation produce huge amounts of rich high-dimensional information. There is a consequent need for flexible means to combine diverse pieces of such information to form useful derivative outputs, and to display those immediately. Here we demonstrate this capability in a DNA-based system that takes two input numbers, represented in DNA strands, and returns the result of their multiplication, writing this as a number in a display. Unlike a conventional calculator, this system operates by selecting the result from a library of solutions rather than through logic operations. The multiplicative example demonstrated here illustrates a much more general capability-to generate a unique output for any distinct pair of DNA inputs. The system thereby functions as a lookup table and could be a key component in future, more powerful data-processing systems for diagnostics and sensing. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Basic Research Program of China (973 Program)[2013CB932800] ; National Basic Research Program of China (973 Program)[2012CB932600] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000367569500002 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | MOLECULAR COMPUTATION ; CIRCUITS |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2077 |
专题 | 生命科学与技术学院_特聘教授组_樊春海组 |
通讯作者 | Fan, Chunhai |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Div Phys Biol, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai 201800, Peoples R China 3.Aarhus Univ, Ctr DNA Nanotechnol, Dept Chem, DK-8000 Aarhus, Denmark 4.Aarhus Univ, Ctr DNA Nanotechnol, iNANO, DK-8000 Aarhus, Denmark 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Liu, Huajie,Wang, Jianbang,Song, Shiping,et al. A DNA-based system for selecting and displaying the combined result of two input variables[J]. NATURE COMMUNICATIONS,2015,6. |
APA | Liu, Huajie,Wang, Jianbang,Song, Shiping,Fan, Chunhai,&Gothelf, Kurt V..(2015).A DNA-based system for selecting and displaying the combined result of two input variables.NATURE COMMUNICATIONS,6. |
MLA | Liu, Huajie,et al."A DNA-based system for selecting and displaying the combined result of two input variables".NATURE COMMUNICATIONS 6(2015). |
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