A DNA-based system for selecting and displaying the combined result of two input variables
Liu, Huajie1,2,3,4; Wang, Jianbang1,2; Song, Shiping1,2; Fan, Chunhai1,2,5; Gothelf, Kurt V.3,4
2015-12
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号6
发表状态已发表
DOI10.1038/ncomms10089
摘要Oligonucleotide-based technologies for biosensing or bio-regulation produce huge amounts of rich high-dimensional information. There is a consequent need for flexible means to combine diverse pieces of such information to form useful derivative outputs, and to display those immediately. Here we demonstrate this capability in a DNA-based system that takes two input numbers, represented in DNA strands, and returns the result of their multiplication, writing this as a number in a display. Unlike a conventional calculator, this system operates by selecting the result from a library of solutions rather than through logic operations. The multiplicative example demonstrated here illustrates a much more general capability-to generate a unique output for any distinct pair of DNA inputs. The system thereby functions as a lookup table and could be a key component in future, more powerful data-processing systems for diagnostics and sensing.
收录类别SCI
语种英语
资助项目National Basic Research Program of China (973 Program)[2013CB932800] ; National Basic Research Program of China (973 Program)[2012CB932600]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000367569500002
出版者NATURE PUBLISHING GROUP
WOS关键词MOLECULAR COMPUTATION ; CIRCUITS
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2077
专题生命科学与技术学院_特聘教授组_樊春海组
通讯作者Fan, Chunhai
作者单位1.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Div Phys Biol, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai 201800, Peoples R China
3.Aarhus Univ, Ctr DNA Nanotechnol, Dept Chem, DK-8000 Aarhus, Denmark
4.Aarhus Univ, Ctr DNA Nanotechnol, iNANO, DK-8000 Aarhus, Denmark
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Liu, Huajie,Wang, Jianbang,Song, Shiping,et al. A DNA-based system for selecting and displaying the combined result of two input variables[J]. NATURE COMMUNICATIONS,2015,6.
APA Liu, Huajie,Wang, Jianbang,Song, Shiping,Fan, Chunhai,&Gothelf, Kurt V..(2015).A DNA-based system for selecting and displaying the combined result of two input variables.NATURE COMMUNICATIONS,6.
MLA Liu, Huajie,et al."A DNA-based system for selecting and displaying the combined result of two input variables".NATURE COMMUNICATIONS 6(2015).
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