A Silk Cranial Fixation System for Neurosurgery
Liu, Keyin1; Shi, Zhifeng2; Zhang, Shaoqing3; Zhou, Zhitao1,4; Sun, Long1; Xu, Tao2; Zhang, Yeshun5; Zhang, Guozheng5; Li, Xinxin1,4,6; Chen, Liang2; Mao, Ying2; Tao, Tiger H.1,3,4,6
2018-03-21
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
Volume7Issue:6
Status已发表
DOI10.1002/adhm.201701359
AbstractCranial fixation should be safe, reliable, ideally degradable, and produce no hazardous residues and no artifacts on neuroimaging. Protein-based fixation devices offer an exciting opportunity for this application. Here, the preclinical development and in vivo efficacy verification of a silk cranial fixation system in functional models are reported by addressing key challenges toward clinical use. A comprehensive study on this fixation system in rodent and canine animal models for up to 12 months is carried out. The silk fixation system shows a superb performance on the long-term stability of the internal structural support for cranial flap fixation and bone reconnection and has good magnetic resonance imaging compatibility, and tolerability to high dose radiotherapy, underscoring the favorable clinical application of this system for neurosurgery compared to the current gold standard.
Keywordcranial fixation neurosurgery silk fibroin
Indexed BySCI
Language英语
Funding ProjectShanghai Sailing Program[16YF1415200]
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000428311900016
PublisherWILEY
WOS KeywordMECHANICAL-PROPERTIES ; RISK-FACTORS ; FIBROIN ; DEGRADATION ; FILMS ; INFECTION ; REMOVAL ; DEVICES ; BRAIN
Original Document TypeArticle
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20228
Collection物质科学与技术学院_特聘教授组_陶虎组
Corresponding AuthorMao, Ying; Tao, Tiger H.
Affiliation1.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
2.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China
3.Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA
4.Univ Chinese Acad Sci, Sch Grad Study, Beijing 100049, Peoples R China
5.Jiangsu Univ Sci & Technol, Sericultural Res Inst, Coll Biotechnol, Zhenjiang 212003, Jiangsu, Peoples R China
6.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
Corresponding Author AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Liu, Keyin,Shi, Zhifeng,Zhang, Shaoqing,et al. A Silk Cranial Fixation System for Neurosurgery[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(6).
APA Liu, Keyin.,Shi, Zhifeng.,Zhang, Shaoqing.,Zhou, Zhitao.,Sun, Long.,...&Tao, Tiger H..(2018).A Silk Cranial Fixation System for Neurosurgery.ADVANCED HEALTHCARE MATERIALS,7(6).
MLA Liu, Keyin,et al."A Silk Cranial Fixation System for Neurosurgery".ADVANCED HEALTHCARE MATERIALS 7.6(2018).
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