ShanghaiTech University Knowledge Management System
A Silk Cranial Fixation System for Neurosurgery | |
Liu, Keyin1; Shi, Zhifeng2; Zhang, Shaoqing3; Zhou, Zhitao1,4; Sun, Long1; Xu, Tao2; Zhang, Yeshun5; Zhang, Guozheng5; Li, Xinxin1,4,6; Chen, Liang2 | |
2018-03-21 | |
发表期刊 | ADVANCED HEALTHCARE MATERIALS |
ISSN | 2192-2640 |
卷号 | 7期号:6 |
发表状态 | 已发表 |
DOI | 10.1002/adhm.201701359 |
摘要 | Cranial fixation should be safe, reliable, ideally degradable, and produce no hazardous residues and no artifacts on neuroimaging. Protein-based fixation devices offer an exciting opportunity for this application. Here, the preclinical development and in vivo efficacy verification of a silk cranial fixation system in functional models are reported by addressing key challenges toward clinical use. A comprehensive study on this fixation system in rodent and canine animal models for up to 12 months is carried out. The silk fixation system shows a superb performance on the long-term stability of the internal structural support for cranial flap fixation and bone reconnection and has good magnetic resonance imaging compatibility, and tolerability to high dose radiotherapy, underscoring the favorable clinical application of this system for neurosurgery compared to the current gold standard. |
关键词 | cranial fixation neurosurgery silk fibroin |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | Shanghai Sailing Program[16YF1415200] |
WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
WOS记录号 | WOS:000428311900016 |
出版者 | WILEY |
WOS关键词 | MECHANICAL-PROPERTIES ; RISK-FACTORS ; FIBROIN ; DEGRADATION ; FILMS ; INFECTION ; REMOVAL ; DEVICES ; BRAIN |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20228 |
专题 | 物质科学与技术学院_特聘教授组_陶虎组 信息科学与技术学院_特聘教授组_李昕欣组 |
通讯作者 | Mao, Ying; Tao, Tiger H. |
作者单位 | 1.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China 2.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China 3.Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA 4.Univ Chinese Acad Sci, Sch Grad Study, Beijing 100049, Peoples R China 5.Jiangsu Univ Sci & Technol, Sericultural Res Inst, Coll Biotechnol, Zhenjiang 212003, Jiangsu, Peoples R China 6.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Liu, Keyin,Shi, Zhifeng,Zhang, Shaoqing,et al. A Silk Cranial Fixation System for Neurosurgery[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(6). |
APA | Liu, Keyin.,Shi, Zhifeng.,Zhang, Shaoqing.,Zhou, Zhitao.,Sun, Long.,...&Tao, Tiger H..(2018).A Silk Cranial Fixation System for Neurosurgery.ADVANCED HEALTHCARE MATERIALS,7(6). |
MLA | Liu, Keyin,et al."A Silk Cranial Fixation System for Neurosurgery".ADVANCED HEALTHCARE MATERIALS 7.6(2018). |
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