A Silk Cranial Fixation System for Neurosurgery
Liu, Keyin1; Shi, Zhifeng2; Zhang, Shaoqing3; Zhou, Zhitao1,4; Sun, Long1; Xu, Tao2; Zhang, Yeshun5; Zhang, Guozheng5; Li, Xinxin1,4,6; Chen, Liang2
2018-03-21
发表期刊ADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
卷号7期号:6
发表状态已发表
DOI10.1002/adhm.201701359
摘要

Cranial fixation should be safe, reliable, ideally degradable, and produce no hazardous residues and no artifacts on neuroimaging. Protein-based fixation devices offer an exciting opportunity for this application. Here, the preclinical development and in vivo efficacy verification of a silk cranial fixation system in functional models are reported by addressing key challenges toward clinical use. A comprehensive study on this fixation system in rodent and canine animal models for up to 12 months is carried out. The silk fixation system shows a superb performance on the long-term stability of the internal structural support for cranial flap fixation and bone reconnection and has good magnetic resonance imaging compatibility, and tolerability to high dose radiotherapy, underscoring the favorable clinical application of this system for neurosurgery compared to the current gold standard.

关键词cranial fixation neurosurgery silk fibroin
收录类别SCI ; SCIE
语种英语
资助项目Shanghai Sailing Program[16YF1415200]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
WOS类目Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号WOS:000428311900016
出版者WILEY
WOS关键词MECHANICAL-PROPERTIES ; RISK-FACTORS ; FIBROIN ; DEGRADATION ; FILMS ; INFECTION ; REMOVAL ; DEVICES ; BRAIN
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20228
专题物质科学与技术学院_特聘教授组_陶虎组
信息科学与技术学院_特聘教授组_李昕欣组
通讯作者Mao, Ying; Tao, Tiger H.
作者单位1.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
2.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China
3.Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA
4.Univ Chinese Acad Sci, Sch Grad Study, Beijing 100049, Peoples R China
5.Jiangsu Univ Sci & Technol, Sericultural Res Inst, Coll Biotechnol, Zhenjiang 212003, Jiangsu, Peoples R China
6.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Liu, Keyin,Shi, Zhifeng,Zhang, Shaoqing,et al. A Silk Cranial Fixation System for Neurosurgery[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(6).
APA Liu, Keyin.,Shi, Zhifeng.,Zhang, Shaoqing.,Zhou, Zhitao.,Sun, Long.,...&Tao, Tiger H..(2018).A Silk Cranial Fixation System for Neurosurgery.ADVANCED HEALTHCARE MATERIALS,7(6).
MLA Liu, Keyin,et al."A Silk Cranial Fixation System for Neurosurgery".ADVANCED HEALTHCARE MATERIALS 7.6(2018).
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