Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors

doi:10.1177/1744806918769492

	Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors
	Bao, Fenghua 1,2,3; Li, Chang-Lin 1,2,3,4; Chen, Xu-Qiao 5; Lu, Ying-Jin 1,2,3,4; Bao, Lan5,6 ; Zhang, Xu1,2,3,6
	2018-04-10
发表期刊	MOLECULAR PAIN (IF:2.8[JCR-2023],3.2[5-Year])
ISSN	1744-8069
卷号	14
发表状态	已发表
DOI	10.1177/1744806918769492
摘要	Opioid receptors play an important role in mediating the spinal analgesia. The mu-opioid receptor is the major target of opioid drugs widely used in clinics. However, the regulatory mechanisms of analgesic effect and tolerance for clinical mu-opioid receptor-targeting opioids remain to be fully investigated. Previous studies showed the interaction of delta-opioid receptor with mu-opioid receptor to form the mu-opioid receptor/delta-opioid receptor heteromers that could be processed in the degradation pathway after delta-opioid receptor agonist treatment. Here, we showed that clinical mu-opioid receptor-targeting opioids, morphine, fentanyl, and methadone, but not tramadol, caused mu-opioid receptor co-internalization with delta-opioid receptors in both transfected human embryonic kidney 293 cells and primary sensory neurons. Prolonged treatment of morphine led to mu-opioid receptor co-degradation with delta-opioid receptors. Furthermore, fentanyl and methadone, but not tramadol, induced the drug tolerance similar to morphine. Thus, the clinical mu-opioid receptor-targeting opioids including morphine, fentanyl, and methadone induce mu-opioid receptor co-internalization with delta-opioid receptors, which may be involved in the analgesic tolerance of these opioids.
关键词	mu-opioid receptor clinical opioids morphine receptor internalization
收录类别	SCI ; SCIE
语种	英语
资助项目	Key Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDY-SSW-SMC007]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000429904700001
出版者	SAGE PUBLICATIONS INC
WOS关键词	PROTEIN-COUPLED RECEPTORS ; KNOCK-OUT MICE ; MORPHINE ANTINOCICEPTIVE TOLERANCE ; DORSAL-ROOT GANGLIA ; OPIATE TOLERANCE ; BETA-ARRESTIN ; DESENSITIZATION ; TRAFFICKING ; DEPENDENCE ; ANALGESIA
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20220
专题	生命科学与技术学院_特聘教授组_鲍岚组生命科学与技术学院_特聘教授组_张旭组
通讯作者	Zhang, Xu
作者单位	1.Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, State Key Lab Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Shanghai, Peoples R China 4.Chinese Acad Sci, XuHui Cent Hosp, Shanghai Clin Res Ctr, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Bao, Fenghua,Li, Chang-Lin,Chen, Xu-Qiao,et al. Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors[J]. MOLECULAR PAIN,2018,14.
APA	Bao, Fenghua,Li, Chang-Lin,Chen, Xu-Qiao,Lu, Ying-Jin,Bao, Lan,&Zhang, Xu.(2018).Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors.MOLECULAR PAIN,14.
MLA	Bao, Fenghua,et al."Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors".MOLECULAR PAIN 14(2018).