The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination

doi:10.1002/glia.24233

	The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination
	Suo, Na 1; He, Bingqing1,2,3 ; Cui, Shihao 1,2; Yang, Ying1,2,3 ; Wang, Min 1; Yuan, Qianting 1; Xie, Xin1,2,3,4,5
	2022-10
发表期刊	GLIA (IF:5.4[JCR-2023],6.6[5-Year])
ISSN	0894-1491
EISSN	1098-1136
发表状态	已发表
DOI	10.1002/glia.24233
摘要	Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs, differentiated from oligodendrocyte precursor cells (OPCs), are important for myelination during development and myelin repair in CNS demyelinating disease. To identify mechanisms of myelin development and remyelination after myelin damage is of great clinical interest. Here we show that the orphan G protein-coupled receptor GPR149, enriched in OPCs, negatively regulate OPC to OL differentiation, myelination, as well as remyelination. The expression of GPR149 is downregulated during OPCs differentiation into OLs. GPR149 deficiency does not affect the number of OPCs, but promotes OPC to OL differentiation which results in earlier development of myelin. In cuprizone-induced demyelination model, GPR149 deficiency significantly enhances myelin regeneration. Further study indicates that GPR149 may regulate OL differentiation and myelin formation via MAPK/ERK pathway. Our study suggests that deleting or blocking GPR149 might be an intriguing way to promote myelin repair in demyelinating diseases.
关键词	GPR149 MAPK ERK pathway myelination oligodendrocyte oligodendrocyte progenitor cell remyelination
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Ministry of Science and Technology China Brain Initiative["2022ZD0204701",82121005] ; Chinese Academy of Sciences["E1G707R05","XDA16010202"] ; National Natural Science Foundation of China[82121005,81730099,82003723]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000816740400001
出版者	WILEY
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/197839
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_谢欣组
通讯作者	Xie, Xin
作者单位	1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 5.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Suo, Na,He, Bingqing,Cui, Shihao,et al. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination[J]. GLIA,2022.
APA	Suo, Na.,He, Bingqing.,Cui, Shihao.,Yang, Ying.,Wang, Min.,...&Xie, Xin.(2022).The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.GLIA.
MLA	Suo, Na,et al."The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination".GLIA (2022).