Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations
Khan, Asifullah1,2; Tian, Lei1; Zhang, Chao1; Yuan, Kai1; Xu, Shuhua1,3,4
2016-01-05
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6
发表状态已发表
DOI10.1038/srep18755
摘要The glycine amidinotransferase gene (GATM) plays a vital role in energy metabolism in muscle tissues and is associated with multiple clinically important phenotypes. However, the genetic diversity of the GATM gene remains poorly understood within and between human populations. Here we analyzed the 1,000 Genomes Project data through population genetics approaches and observed significant genetic diversity across the GATM gene among various continental human populations. We observed considerable variations in GATM allele frequencies and haplotype composition among different populations. Substantial genetic differences were observed between East Asian and European populations (F-ST = 0.56). In addition, the frequency of a distinct major GATM haplotype in these groups was congruent with population-wide diversity at this locus. Furthermore, we identified GATM as the top differentiated gene compared to the other statin drug response-associated genes. Composite multiple analyses identified signatures of positive selection at the GATM locus, which was estimated to have occurred around 850 generations ago in European populations. As GATM catalyzes the key step of creatine biosynthesis involved in energy metabolism, we speculate that the European prehistorical demographic transition from hunter-gatherer to farming cultures was the driving force of selection that fulfilled creatine-based metabolic requirement of the populations.
收录类别SCI
语种英语
资助项目NSFC Research Fellowship for International Young Scientists[31550110218]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000368356100001
出版者NATURE PUBLISHING GROUP
WOS关键词POSITIVE SELECTION ; KIDNEY-DISEASE ; RENAL-FUNCTION ; DEFICIENCY ; CREATINE ; ASSOCIATION ; METABOLISM ; FARMERS ; EUROPE ; GENOME
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1950
专题生命科学与技术学院_特聘教授组_徐书华组
通讯作者Xu, Shuhua
作者单位1.Chinese Acad Sci, Chinese Acad Sci CAS Key Lab Computat Biol, Max Planck Independent Res Grp Populat Genom, CAS MPG Partner Inst Computat Biol PICB,Shanghai, Shanghai 200031, Peoples R China
2.AWKUM, Dept Biochem, Mardan, Khyber Pakhthun, Pakistan
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
4.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Khan, Asifullah,Tian, Lei,Zhang, Chao,et al. Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations[J]. SCIENTIFIC REPORTS,2016,6.
APA Khan, Asifullah,Tian, Lei,Zhang, Chao,Yuan, Kai,&Xu, Shuhua.(2016).Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations.SCIENTIFIC REPORTS,6.
MLA Khan, Asifullah,et al."Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations".SCIENTIFIC REPORTS 6(2016).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Khan, Asifullah]的文章
[Tian, Lei]的文章
[Zhang, Chao]的文章
百度学术
百度学术中相似的文章
[Khan, Asifullah]的文章
[Tian, Lei]的文章
[Zhang, Chao]的文章
必应学术
必应学术中相似的文章
[Khan, Asifullah]的文章
[Tian, Lei]的文章
[Zhang, Chao]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1038@srep18755.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。