Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions

doi:10.1002/anie.201510014

	Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions
	Zhang, Jing 1; Li, Yang 1; Zhang, Fuyuan2 ; Hu, Chenchen 1; Chen, Yiyun1,2
	2016-01-26
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN	1433-7851
卷号	55 期号:5 页码:1872-1875
发表状态	已发表
DOI	10.1002/anie.201510014
摘要	Reported herein is the first visible-light-induced formation of alkoxyl radicals from N-alkoxyphthalimides, and the Hantzsch ester as the reductant is crucial for the reaction. The selective hydrogen atom abstraction by the alkoxyl radical enables C(sp(3))-H allylation and alkenylation reactions under mild reaction conditions at room temperature. Broad substrate variations, including a structurally complexed steroid, undergo the C(sp(3))-H functionalization reaction effectively with high regio- and chemoselectivity.
关键词	allylic compounds C-H functionalization photochemistry alkoxyl radicals reaction mechanisms
收录类别	SCI ; IC ; CCR ; EI
语种	英语
资助项目	National Natural Science Foundation of China[21272260] ; National Natural Science Foundation of China[21472230]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000369854000052
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20160101757015
EI主题词	Chemical reactions ; Photochemical reactions
WOS关键词	HYDROGEN-ATOM TRANSFERS ; C-H BONDS ; STEREOSELECTIVE-SYNTHESIS ; COORDINATION-COMPOUNDS ; TRANSITION STRUCTURES ; N-ALKOXYPHTHALIMIDES ; RELAY CYCLIZATIONS ; ORGANIC-SYNTHESIS ; CARBON RADICALS ; VINYL SULFONES
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1938
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_陈以昀组物质科学与技术学院_硕士生
通讯作者	Chen, Yiyun
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Jing,Li, Yang,Zhang, Fuyuan,et al. Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(5):1872-1875.
APA	Zhang, Jing,Li, Yang,Zhang, Fuyuan,Hu, Chenchen,&Chen, Yiyun.(2016).Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(5),1872-1875.
MLA	Zhang, Jing,et al."Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.5(2016):1872-1875.