Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection

doi:10.1016/j.neuron.2015.12.036

	Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection
	Yao, Yuanyuan 1,2; Li, Xiaoquan 1; Zhang, Baibing 1,2; Yin, Chen 1,2; Liu, Yafeng 3,4; Chen, Weiyu 1,2; Zeng, Shaoqun 3,4; Du, Jiulin1,2,5
	2016-02-03
发表期刊	NEURON (IF:14.7[JCR-2023],16.9[5-Year])
ISSN	0896-6273
卷号	89 期号:3 页码:598-612
发表状态	已发表
DOI	10.1016/j.neuron.2015.12.036
摘要	Animals behave differently in response to visual cues with distinct ethological meaning, a process usually thought to be achieved through differential visual processing. Using a defined zebrafish escape circuit as a model, we found that behavior selection can be implemented at the visuomotor transformation stage through a visually responsive dopaminergic-inhibitory circuit module. In response to non-threatening visual stimuli, hypothalamic dopaminergic neurons and their positively regulated hindbrain inhibitory interneurons increase activity, suppressing synaptic transmission from the visual center to the escape circuit. By contrast, threatening visual stimuli inactivate some of these neurons, resulting in dis-inhibition of the visuomotor transformation and escape generation. The distinct patterns of dopaminergic-inhibitory neural module's visual responses account for this stimulus-specific visuomotor transformation and behavioral control. Thus, our study identifies a behavioral relevance-dependent mechanism that controls visuomotor transformation and behavior selection and reveals that neuromodulation can be tuned by visual cues to help animals generate appropriate responses.
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai[14XD1404100] ; Science and Technology Commission of Shanghai[13ZR1464000]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000373564900017
出版者	CELL PRESS
WOS关键词	VENTRAL TEGMENTAL AREA ; DECISION-MAKING ; MAUTHNER CELL ; SENSORIMOTOR TRANSFORMATION ; NEURONAL CIRCUITS ; OBJECT APPROACH ; GABA NEURONS ; ZEBRAFISH ; ACTIVATION ; HINDBRAIN
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1928
专题	生命科学与技术学院_特聘教授组_杜久林组
通讯作者	Du, Jiulin
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 3.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China 4.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Dept Biomed Engn, Wuhan 430074, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yao, Yuanyuan,Li, Xiaoquan,Zhang, Baibing,et al. Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection[J]. NEURON,2016,89(3):598-612.
APA	Yao, Yuanyuan.,Li, Xiaoquan.,Zhang, Baibing.,Yin, Chen.,Liu, Yafeng.,...&Du, Jiulin.(2016).Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection.NEURON,89(3),598-612.
MLA	Yao, Yuanyuan,et al."Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection".NEURON 89.3(2016):598-612.