Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition
2016-04-07
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
Volume44Issue:6Pages:2514-2527
Status已发表
DOI10.1093/nar/gkw126
AbstractEpithelial-to-mesenchymal transition (EMT) is a complex multistep process in which phenotype switches are mediated by a network of transcription factors (TFs). Systematic characterization of all dynamic TFs controlling EMT state transitions, especially for the intermediate partial-EMT state, represents a highly relevant yet largely unexplored task. Here, we performed a computational analysis that integrated time-course EMT transcriptomic data with public cistromic data and identified three synergistic master TFs (ETS2, HNF4A and JUNB) that regulate the transition through the partial-EMT state. Overexpression of these regulators predicted a poor clinical outcome, and their elimination readily abolished TGF-beta-induced EMT. Importantly, these factors utilized a clique motif, physically interact and their cumulative binding generally characterized EMT-associated genes. Furthermore, analyses of H3K27ac ChIP-seq data revealed that ETS2, HNF4A and JUNB are associated with super-enhancers and the administration of BRD4 inhibitor readily abolished TGF-beta-induced EMT. These findings have implications for systematic discovery of master EMT regulators and super-enhancers as novel targets for controlling metastasis.
Indexed BySCI
Language英语
Funding ProjectScience and Technology Commission of Shanghai Municipality[12DZ1910800]
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000374570500014
PublisherOXFORD UNIV PRESS
WOS KeywordTGF-BETA ; SUPER-ENHANCERS ; REGULATORY NETWORKS ; CELL-MIGRATION ; CANCER ; EXPRESSION ; PROGRESSION ; METASTASIS ; INHIBITION ; ACTIVATION
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1874
Collection生命科学与技术学院
生命科学与技术学院_特聘教授组_王鹏组
生命科学与技术学院_硕士生
Corresponding AuthorWang, Peng
Affiliation
1.Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, 100 Haike Rd,Zhangjiang High Tech Pk, Shanghai 201210, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China
4.Shanghai Univ, Sch Life Sci, 333 Nanchen Rd, Shanghai 200444, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang High Tech Pk, Shanghai 201203, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd,Zhangjiang High Tech Pk, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Chang, Hongyuan,Liu, Yuwei,Xue, Mengzhu,et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition[J]. NUCLEIC ACIDS RESEARCH,2016,44(6):2514-2527.
APA Chang, Hongyuan.,Liu, Yuwei.,Xue, Mengzhu.,Liu, Haiyue.,Du, Shaowei.,...&Wang, Peng.(2016).Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition.NUCLEIC ACIDS RESEARCH,44(6),2514-2527.
MLA Chang, Hongyuan,et al."Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition".NUCLEIC ACIDS RESEARCH 44.6(2016):2514-2527.
Files in This Item: Download All
File Name/Size DocType Version Access License
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Chang, Hongyuan]'s Articles
[Liu, Yuwei]'s Articles
[Xue, Mengzhu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chang, Hongyuan]'s Articles
[Liu, Yuwei]'s Articles
[Xue, Mengzhu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chang, Hongyuan]'s Articles
[Liu, Yuwei]'s Articles
[Xue, Mengzhu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.1093@nar@gkw126.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.