Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br

doi:10.1021/acs.jmedchem.1c01859

KMS > 免疫化学研究所 > 特聘教授组 > Richard A. Lerner组

	Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br
	Hou, Wei1,2 ; Xu, Hongtao3
	2022-03-24
发表期刊	JOURNAL OF MEDICINAL CHEMISTRY (IF:6.8[JCR-2023],7.1[5-Year])
ISSN	0022-2623
EISSN	1520-4804
卷号	65 期号:6
发表状态	已发表
DOI	10.1021/acs.jmedchem.1c01859
摘要	Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the treatment of a range of diseases. Through tremendous effort, considerable knowledge has been acquired to understand the complex chemical properties and biological activities of selenium, especially after its incorporation into bioactive molecules. From this perspective, we compiled extensive literature evidence to summarize and critically discuss the relationship between the pharmacological activities and chemical properties of selenium compounds and the strategic incorporation of selenium into organic molecules, especially bioactive heterocycles and natural products. We also provide perspectives regarding the challenges in selenium-based medicinal chemistry and future research directions
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[21907085,21977070,"U19A2011"] ; Natural Science Foundation of Shanghai[21ZR1442900]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000790749000003
出版者	AMER CHEMICAL SOC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/185370
专题	免疫化学研究所_特聘教授组_抗体设计学实验室
通讯作者	Hou, Wei; Xu, Hongtao
作者单位	1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 2.Zhejiang Univ Technol, Inst Drug Dev & Chem Biol, Hangzhou 310014, Peoples R China 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Hou, Wei,Xu, Hongtao. Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br[J]. JOURNAL OF MEDICINAL CHEMISTRY,2022,65(6).
APA	Hou, Wei,&Xu, Hongtao.(2022).Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br.JOURNAL OF MEDICINAL CHEMISTRY,65(6).
MLA	Hou, Wei,et al."Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br".JOURNAL OF MEDICINAL CHEMISTRY 65.6(2022).