Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

doi:10.1371/journal.ppat.1010288

KMS > 免疫化学研究所 > 特聘教授组 > Roger D. Kornberg组

	Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation
	Stroehlein, Andreas J.1; Korhonen, Pasi K.1; Lee, V. Vern 2; Ralph, Stuart A.2; Mentink-Kane, Margaret 3; You, Hong 4; McManus, Donald P.4; Tchuente, Louis-Albert Tchuem 5,6; Stothard, J. Russell 6; Kaur, Parwinder 7; Dudchenko, Olga 8,9; Aiden, Erez Lieberman7,8,9,10,11 ; Yang, Bicheng 12; Yang, Huanming 13,14; Emery, Aidan M.15,16; Webster, Bonnie L.15,16; Brindley, Paul J.17; Rollinson, David 15,16; Chang, Bill C. H.1; Gasser, Robin B.1; Young, Neil D.1
	2022-02-01
发表期刊	PLOS PATHOGENS
ISSN	1553-7366
EISSN	1553-7374
卷号	18 期号:2
发表状态	已发表
DOI	10.1371/journal.ppat.1010288
摘要	["Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenital tissues, and can lead to increased susceptibility to HIV/AIDS and squamous cell carcinoma of the bladder. To complement available treatment programs and break the transmission of disease, sound knowledge and understanding of the biology and ecology of S. haematobium is required. Hybridisation/introgression events and molecular variation among members of the S. haematobium-group might effect important biological and/or disease traits as well as the morbidity of disease and the effectiveness of control programs including mass drug administration. Here we report the first chromosome-contiguous genome for a well-defined laboratory line of this blood fluke. An exploration of this genome using transcriptomic data for all key developmental stages allowed us to refine gene models (including non-coding elements) and annotations, discover 'new' genes and transcription profiles for these stages, likely linked to development and/or pathogenesis. Molecular variation within S. haematobium among some geographical locations in Africa revealed unique genomic 'signatures' that matched species other than S. haematobium, indicating the occurrence of introgression events. The present reference genome (designated Shae.V3) and the findings from this study solidly underpin future functional genomic and molecular investigations of S. haematobium and accelerate systematic, large-scale population genomics investigations, with a focus on improved and sustained control of urogenital schistosomiasis.","Author summary","More than 100 million people are infected with the carcinogenic blood fluke Schistosoma haematobium, the aetiological agent of urogenital schistosomiasis-a neglected tropical disease (NTD). In spite of its major significance, little is known about this fluke, its interactions with the human and snail intermediate hosts and the pathogenesis of the urogenital form of schistosomiasis at the molecular and biochemical levels. To enable research in these areas, we report the first chromosome-level genome and markedly enhanced gene models for S. haematobium. Comparative genomic analyses also reveal evidence of past introgression events between or among closely related schistosome species. This present reference genome for S. haematobium and the findings from this study should underpin future functional genomic and molecular investigations of S. haematobium and accelerate systematic, large-scale population genomics investigations, with a focus on improved control of urogenital schistosomiasis."]
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收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Microbiology ; Parasitology ; Virology
WOS类目	Microbiology ; Parasitology ; Virology
WOS记录号	WOS:000793319500002
出版者	PUBLIC LIBRARY SCIENCE
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/185361
专题	免疫化学研究所_特聘教授组_结构生物化学实验室
通讯作者	Gasser, Robin B.; Young, Neil D.
作者单位	1.Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia 2.Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Dept Biochem & Pharmacol, Parkville, Vic, Australia 3.NIAID, NIH, Schistosomiasis Resource Ctr, Biomed Res Inst, Rockville, MD USA 4.QIMR Berghofer Med Res Inst, Immunol Dept, Brisbane, Qld, Australia 5.Univ Yaounde I, Fac Sci, Yaounde, Cameroon 6.Univ Liverpool Liverpool Sch Trop Med, Dept Parasitol, Liverpool, Merseyside, England 7.Univ Western Australia, UWA Sch Agr & Environm, Perth, WA, Australia 8.Baylor Coll Med, Ctr Genome Architecture, Dept Mol & Human Genet, Houston, TX 77030 USA 9.Rice Univ, Ctr Theoret Biol Phys, Houston, TX USA 10.ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong, Peoples R China 11.Inst MIT & Harvard, Cambridge, MA USA 12.BGI Grp, BGI Australia, CBCRB Bldg, Herston, Qld, Australia 13.BGI Shenzhen, Shenzhen, Peoples R China 14.BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China 15.Nat Hist Museum, Parasites & Vectors Div, London, England 16.London Ctr Neglected Trop Dis Res LCNTDR, London, England 17.George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA
推荐引用方式 GB/T 7714	Stroehlein, Andreas J.,Korhonen, Pasi K.,Lee, V. Vern,et al. Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation[J]. PLOS PATHOGENS,2022,18(2).
APA	Stroehlein, Andreas J..,Korhonen, Pasi K..,Lee, V. Vern.,Ralph, Stuart A..,Mentink-Kane, Margaret.,...&Young, Neil D..(2022).Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation.PLOS PATHOGENS,18(2).
MLA	Stroehlein, Andreas J.,et al."Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation".PLOS PATHOGENS 18.2(2022).