Microfluidic technology enhances the potential of human pluripotent stem cells

doi:10.1016/j.bbrc.2015.12.058

KMS > 免疫化学研究所

	Microfluidic technology enhances the potential of human pluripotent stem cells
	Gagliano, Onelia 1,2; Elvassore, Nicola 1,2; Luni, Camilla1,2,3
	2016-05-06
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:2.5[JCR-2023],2.7[5-Year])
ISSN	0006-291X
卷号	473 期号:3 页码:683-687
发表状态	已发表
DOI	10.1016/j.bbrc.2015.12.058
摘要	Since the discovery of human somatic cell reprogramming, human induced pluripotent stem cells (hiPSC) have been increasingly recognized as the landmark for development of organs-on-chip. hiPSCs show a remarkable plasticity that is related to their ability to promptly respond to the surrounding environment. In vitro, the soluble culture microenvironment, with its critical balance between exogenous and cell secreted factors, plays a great role in inducing hiPSC response, for both preserving pluripotency and controlling differentiation stages. Exploring the complexity of hiPSC microenvironment requires new experimental tools, as a tight control is limited within conventional culture dishes. Microfluidic technology is particularly attractive in hiPSC research because of its ability to mimic specific environmental cues by accurate control of soluble factors with high spatiotemporal resolution and in a high-throughput fashion. In this review, we highlight recent progress in hiPSC research enabled by microfluidic technology as well as new emerging scenarios. (C) 2016 Published by Elsevier Inc.
关键词	Pluripotent stem cell Embryonic stem cell Microfluidic Organ on chip Tissue on chip Reprogramming Differentiation
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000375968400004
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	DIFFERENTIATION ; CULTURE
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1838
专题	免疫化学研究所免疫化学研究所_特聘教授组_生物工程学实验室
通讯作者	Luni, Camilla
作者单位	1.Univ Padua, Dept Ind Engn, I-35100 Padua, Italy 2.Venetian Inst Mol Med, Padua, Italy 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Gagliano, Onelia,Elvassore, Nicola,Luni, Camilla. Microfluidic technology enhances the potential of human pluripotent stem cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,473(3):683-687.
APA	Gagliano, Onelia,Elvassore, Nicola,&Luni, Camilla.(2016).Microfluidic technology enhances the potential of human pluripotent stem cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,473(3),683-687.
MLA	Gagliano, Onelia,et al."Microfluidic technology enhances the potential of human pluripotent stem cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 473.3(2016):683-687.