Connecting Ras and CTP synthase in Drosophila

doi:10.1016/j.yexcr.2022.113155

	Connecting Ras and CTP synthase in Drosophila
	Zhou YF(周有芳); Liu JN(刘竞男); Liu JL(刘冀珑)
	2022-04
发表期刊	EXPERIMENTAL CELL RESEARCH (IF:3.3[JCR-2023],3.3[5-Year])
ISSN	0014-4827
卷号	416 期号:1 页码:113155
发表状态	已发表
DOI	10.1016/j.yexcr.2022.113155
摘要	CTP synthase (CTPS), the enzyme responsible for the last step of de novo synthesis of CTP, forms filamentous structures termed cytoophidia in all three domains of life. Here we report that oncogenic Ras regulates cytoophidium formation in Drosophila intestines. Overexpressing active Ras induces elongate and abundant cytoophidia in intestinal stem cells (ISCs) and enteroblasts (EBs). Knocking-down CTPS in ISCs/EBs suppresses the over- proliferation phenotype induced by ectopic expression of active Ras. Moreover, disrupting cytoophidium formation increases the number of proliferating cells in the background of overexpressing active Ras. Therefore, our results demonstrate a link between Ras and CTPS.
关键词	CTP synthase Drosophila Intestine stem cell Ras Cytoophidium
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/183393
专题	生命科学与技术学院_PI研究组_刘冀珑组生命科学与技术学院_博士生
通讯作者	Liu JL(刘冀珑)
作者单位	School of Life Science and Technology, ShanghaiTech University, Shanghai, China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhou YF,Liu JN,Liu JL. Connecting Ras and CTP synthase in Drosophila[J]. EXPERIMENTAL CELL RESEARCH,2022,416(1):113155.
APA	Zhou YF,Liu JN,&Liu JL.(2022).Connecting Ras and CTP synthase in Drosophila.EXPERIMENTAL CELL RESEARCH,416(1),113155.
MLA	Zhou YF,et al."Connecting Ras and CTP synthase in Drosophila".EXPERIMENTAL CELL RESEARCH 416.1(2022):113155.