An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline

doi:10.1095/biolreprod.115.137497

	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline
	Mak, Winifred 1,3; Fang, Caodi 1,3; Holden, Tobias 1; Dratver, Milana Bockhur 1; Lin, Haifan1,2,3,4,5,6
	2016-06
发表期刊	BIOLOGY OF REPRODUCTION (IF:3.1[JCR-2023],3.7[5-Year])
ISSN	0006-3363
卷号	94 期号:6
发表状态	已发表
DOI	10.1095/biolreprod.115.137497
摘要	Pumilio/FBF (PUF) proteins are a highly conserved family of translational regulators. The Drosophila PUF protein, Pumilio, is crucial for germline establishment and fertility. In mammals, primordial folliculogenesis is a key process that establishes the initial cohort of female mammalian germ cells prior to birth, and this primordial follicle pool is a prerequisite for female reproductive competence. We sought to understand whether PUF proteins have a conserved role in mammals during primordial folliculogenesis and female reproductive competency. In mammals, two homologs of Pumilio exist: Pumilio 1 (Pum1) and Pum2. Here, we report that PUMILIO (PUM) 1 plays an important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency, whereas PUM2 does not have a detectable function in these processes. Furthermore, we show that PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein. Our study reveals an important role of translational regulation in mammalian female germ cell development.
关键词	meiosis primordial folliculogenesis Pumilio RNA binding protein subfertility translational regulator
收录类别	SCI
语种	英语
资助项目	National Institutes of Health[2K12HD047018-11]
WOS研究方向	Reproductive Biology
WOS类目	Reproductive Biology
WOS记录号	WOS:000379572800010
出版者	SOC STUDY REPRODUCTION
WOS关键词	RNA-BINDING PROTEINS ; MESSENGER-RNA ; STEM-CELLS ; MOUSE OOCYTES ; X-CHROMOSOME ; GENE ENCODES ; DROSOPHILA ; HOMOLOG ; DOMAIN ; NANOS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1816
专题	生命科学与技术学院免疫化学研究所_特聘教授组_干细胞生物学实验室
通讯作者	Mak, Winifred; Lin, Haifan
作者单位	1.Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT USA 2.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA 3.Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, New Haven, CT USA 4.Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA 5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所; 生命科学与技术学院
推荐引用方式 GB/T 7714	Mak, Winifred,Fang, Caodi,Holden, Tobias,et al. An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline[J]. BIOLOGY OF REPRODUCTION,2016,94(6).
APA	Mak, Winifred,Fang, Caodi,Holden, Tobias,Dratver, Milana Bockhur,&Lin, Haifan.(2016).An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.BIOLOGY OF REPRODUCTION,94(6).
MLA	Mak, Winifred,et al."An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline".BIOLOGY OF REPRODUCTION 94.6(2016).