Serial femto-second crystallography datasets from G protein-coupled receptors
White, Thomas A.1; Barty, Anton1; Liu, Wei2,3; Ishchenko, Andrii4,5; Zhang, Haitao4,5; Gati, Cornelius6; Zatsepin, Nadia A.7; Basu, Shibom2,3; Oberthuer, Dominik1; Metz, Markus1
2016-08
发表期刊SCIENTIFIC DATA
ISSN2052-4463
卷号3
发表状态已发表
DOI10.1038/sdata.2016.57
摘要We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human delta-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.
收录类别SCI
语种英语
资助项目Medical Research Council[MC_UP_A025_1013]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000390225400002
出版者NATURE PUBLISHING GROUP
WOS关键词FEMTOSECOND CRYSTALLOGRAPHY
原始文献类型Article ; Data Paper
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1764
专题iHuman研究所_公共科研平台_同步辐射线站
iHuman研究所_科学装置(X)_膜蛋白同步辐射线站
通讯作者Cherezov, Vadim
作者单位1.DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
2.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA
3.Arizona State Univ, Ctr Appl Struct Discovery, Biodesign Inst, Tempe, AZ 85287 USA
4.Univ Southern Calif, Bridge Inst, Dept Chem & Phys, Los Angeles, CA 90089 USA
5.Univ Southern Calif, Bridge Inst, Dept Astron, Los Angeles, CA 90089 USA
6.MRC, Mol Biol Lab, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England
7.Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA
8.Paul Scherrer Inst, CH-5232 Villigen, Switzerland
9.ShanghaiTech Univ, iHuman Inst, 2F Bldg 6,99 Haike Rd, Shanghai 201210, Peoples R China
10.Natl Sci Fdn, BioXFEL Sci & Technol Ctr, 700 Ellicott St, Buffalo, NY 14203 USA
推荐引用方式
GB/T 7714
White, Thomas A.,Barty, Anton,Liu, Wei,et al. Serial femto-second crystallography datasets from G protein-coupled receptors[J]. SCIENTIFIC DATA,2016,3.
APA White, Thomas A..,Barty, Anton.,Liu, Wei.,Ishchenko, Andrii.,Zhang, Haitao.,...&Cherezov, Vadim.(2016).Serial femto-second crystallography datasets from G protein-coupled receptors.SCIENTIFIC DATA,3.
MLA White, Thomas A.,et al."Serial femto-second crystallography datasets from G protein-coupled receptors".SCIENTIFIC DATA 3(2016).
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