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Serial femto-second crystallography datasets from G protein-coupled receptors | |
White, Thomas A.1; Barty, Anton1; Liu, Wei2,3; Ishchenko, Andrii4,5; Zhang, Haitao4,5; Gati, Cornelius6; Zatsepin, Nadia A.7; Basu, Shibom2,3; Oberthuer, Dominik1; Metz, Markus1 | |
2016-08 | |
发表期刊 | SCIENTIFIC DATA |
ISSN | 2052-4463 |
卷号 | 3 |
发表状态 | 已发表 |
DOI | 10.1038/sdata.2016.57 |
摘要 | We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human delta-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Medical Research Council[MC_UP_A025_1013] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000390225400002 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | FEMTOSECOND CRYSTALLOGRAPHY |
原始文献类型 | Article ; Data Paper |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1764 |
专题 | iHuman研究所_公共科研平台_同步辐射线站 iHuman研究所_科学装置(X)_膜蛋白同步辐射线站 |
通讯作者 | Cherezov, Vadim |
作者单位 | 1.DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany 2.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA 3.Arizona State Univ, Ctr Appl Struct Discovery, Biodesign Inst, Tempe, AZ 85287 USA 4.Univ Southern Calif, Bridge Inst, Dept Chem & Phys, Los Angeles, CA 90089 USA 5.Univ Southern Calif, Bridge Inst, Dept Astron, Los Angeles, CA 90089 USA 6.MRC, Mol Biol Lab, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England 7.Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA 8.Paul Scherrer Inst, CH-5232 Villigen, Switzerland 9.ShanghaiTech Univ, iHuman Inst, 2F Bldg 6,99 Haike Rd, Shanghai 201210, Peoples R China 10.Natl Sci Fdn, BioXFEL Sci & Technol Ctr, 700 Ellicott St, Buffalo, NY 14203 USA |
推荐引用方式 GB/T 7714 | White, Thomas A.,Barty, Anton,Liu, Wei,et al. Serial femto-second crystallography datasets from G protein-coupled receptors[J]. SCIENTIFIC DATA,2016,3. |
APA | White, Thomas A..,Barty, Anton.,Liu, Wei.,Ishchenko, Andrii.,Zhang, Haitao.,...&Cherezov, Vadim.(2016).Serial femto-second crystallography datasets from G protein-coupled receptors.SCIENTIFIC DATA,3. |
MLA | White, Thomas A.,et al."Serial femto-second crystallography datasets from G protein-coupled receptors".SCIENTIFIC DATA 3(2016). |
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