MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration

doi:10.1016/j.celrep.2016.07.020

	MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration
	Liu, Zhe 1,2; Wu, Huijuan 2,3; Jiang, Kewu 2,4; Wang, Yanjie 2,3; Zhang, Wenjing 5,6,7; Chu, Qiqi 2; Li, Juan 2; Huang, Huanwei 2; Cai, Tao 2; Ji, Hongbin5,6,7,8 ; Yang, Chun 9; Tang, Nan 2
	2016-08-16
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	16 期号:7 页码:1810-1819
发表状态	已发表
DOI	10.1016/j.celrep.2016.07.020
摘要	The pulmonary alveolar epithelium undergoes extensive regeneration in response to lung injuries, including lung resection. In recent years, our understanding of cell lineage relationships in the pulmonary alveolar epithelium has improved significantly. However, the molecular and cellular mechanisms that regulate pneumonectomy (PNX)-induced alveolar regeneration remain largely unknown. In this study, we demonstrate that mechanical-tension-induced YAP activation in alveolar stem cells plays a major role in promoting post-PNX alveolar regeneration. Our results indicate that JNK and p38MAPK signaling is critical for mediating actin-cytoskeleton-remodeling-induced nuclear YAP expression in alveolar stem cells. Moreover, we show that Cdc42-controlled actin remodeling is required for the activation of JNK, p38, and YAP in post-PNX lungs. Our findings together establish that the Cdc42/F-actin/MAPK/YAP signaling cascade is essential for promoting alveolar regeneration in response to mechanical tension in the lung.
收录类别	SCI
语种	英语
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000381376500004
出版者	CELL PRESS
WOS关键词	STEM-CELLS ; HIPPO PATHWAY ; GROWTH ; YAP/TAZ ; RENEWAL ; SIZE ; JNK
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1753
专题	生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Tang, Nan
作者单位	1.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China 2.Natl Inst Biol Sci, Beijing 102206, Peoples R China 3.Tsinghua Univ, Coll Life Sci, Beijing 100084, Peoples R China 4.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 8.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China 9.Tsinghua Univ, Inst Biomech & Med Engn, Sch Aerosp Engn, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhe,Wu, Huijuan,Jiang, Kewu,et al. MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration[J]. CELL REPORTS,2016,16(7):1810-1819.
APA	Liu, Zhe.,Wu, Huijuan.,Jiang, Kewu.,Wang, Yanjie.,Zhang, Wenjing.,...&Tang, Nan.(2016).MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration.CELL REPORTS,16(7),1810-1819.
MLA	Liu, Zhe,et al."MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration".CELL REPORTS 16.7(2016):1810-1819.