Down-regulation of Risa improves insulin sensitivity by enhancing autophagy
Wang, Yuangao1; Hu, Yanan1; Sun, Chenxia1; Zhuo, Shu1; He, Zhishui1; Wang, Hui1; Yan, Menghong1; Liu, Jun1; Luan, Yi1; Dai, Changgui1
2016-09
发表期刊FASEB JOURNAL
ISSN0892-6638
卷号30期号:9页码:3133-3145
发表状态已发表
DOI10.1096/fj.201500058R
摘要It has been reported that some small noncoding RNAs are involved in the regulation of insulin sensitivity. However, whether long noncoding RNAs also participate in the regulation of insulin sensitivity is still largely unknown. We identified and characterized a long noncoding RNA, regulator of insulin sensitivity and autophagy (Risa), which is a poly(A)(+) cytoplasmic RNA. Overexpression of Risa in mouse primary hepatocytes or C2C12 myotubes attenuated insulin-stimulated phosphorylation of insulin receptor, Akt, and Gsk3, and knockdown of Risa alleviated insulin resistance. Further studies showed that overexpression of Risa in hepatocytes or myotubes decreased autophagy, and knockdown of Risa up-regulated autophagy. Moreover, knockdown of Atg7 or -5 significantly inhibited the effect of knockdown of Risa on insulin resistance, suggesting that knockdown of Risa alleviated insulin resistance via enhancing autophagy. In addition, tail vein injection of adenovirus to knock down Risa enhanced insulin sensitivity and hepatic autophagy in both C57BL/6 and ob/ob mice. Taken together, the data demonstrate that Risa regulates insulin sensitivity by affecting autophagy and suggest that Risa is a potential target for treating insulin-resistance-related diseases.Wang, Y., Hu, Y., Sun, C., Zhuo, S., He, Z., Wang, H., Yan, M., Liu, J., Luan, Y., Dai, C., Yang, Y., Huang, R., Zhou, B., Zhang, F., Zhai, Q. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy.
关键词lncRNA insulin resistance glucose homeostasis ob ob mice
收录类别SCI
语种英语
资助项目Chinese Academy of Sciences[2014KIP106]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS记录号WOS:000382816300014
出版者FEDERATION AMER SOC EXP BIOL
WOS关键词LONG NONCODING RNAS ; ACTIVATES AUTOPHAGY ; SIRT1 ; PHOSPHORYLATION ; METABOLISM ; OBESITY ; STRESS ; OVEREXPRESSION ; EXPRESSION ; SELECTION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1730
专题生命科学与技术学院_特聘教授组_翟琦巍组
通讯作者Zhai, Qiwei
作者单位1.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Inst Nutr Sci, Key Lab Nutr & Metab,Shanghai Inst Biol Sci, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
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Wang, Yuangao,Hu, Yanan,Sun, Chenxia,et al. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy[J]. FASEB JOURNAL,2016,30(9):3133-3145.
APA Wang, Yuangao.,Hu, Yanan.,Sun, Chenxia.,Zhuo, Shu.,He, Zhishui.,...&Zhai, Qiwei.(2016).Down-regulation of Risa improves insulin sensitivity by enhancing autophagy.FASEB JOURNAL,30(9),3133-3145.
MLA Wang, Yuangao,et al."Down-regulation of Risa improves insulin sensitivity by enhancing autophagy".FASEB JOURNAL 30.9(2016):3133-3145.
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