Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors

doi:10.1038/ncomms12650

	Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
	Zhang, Rong-wei 1; Li, Xiao-quan 1; Kawakami, Koichi 2; Du, Jiu-lin1,3,4
	2016-09
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN	2041-1723
卷号	7
发表状态	已发表
DOI	10.1038/ncomms12650
摘要	Glutamatergic retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. However, its initiation and underlying mechanism remain largely elusive. Here using larval zebrafish and multiple in vivo approaches, we discover that bipolar cells (BCs) are responsible for the generation of glutamatergic retinal waves. The wave originates from BC axon terminals (ATs) and propagates laterally to nearby BCs and vertically to downstream RGCs and the optic tectum. Its initiation is triggered by the activation of and consequent glutamate release from BC ATs, and is mediated by the N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) expressed at these ATs. Intercellular asymmetry of NMDAR expression at BC ATs enables the preferential initiation of waves at the temporal retina, where BC ATs express more NMDARs. Thus, our findings indicate that glutamatergic retinal waves are initiated by BCs through a presynaptic NMDA autoreceptor-dependent process.
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation from the Science and Technology Commission of Shanghai[14XD1404100] ; Natural Science Foundation from the Science and Technology Commission of Shanghai[13ZR1446800]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000384969300001
出版者	NATURE PUBLISHING GROUP
WOS关键词	GANGLION-CELLS ; SYNAPTIC-TRANSMISSION ; PATTERNED ACTIVITY ; ZEBRAFISH ; GLUTAMATE ; MECHANISMS ; CIRCUITS ; LIGHT ; PROPAGATION ; ACTIVATION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1727
专题	生命科学与技术学院_特聘教授组_杜久林组
通讯作者	Zhang, Rong-wei; Du, Jiu-lin
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci,State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Natl Inst Genet, Div Mol & Dev Biol, 1111 Yata, Mishima, Shizuoka 4118540, Japan 3.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Rong-wei,Li, Xiao-quan,Kawakami, Koichi,et al. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors[J]. NATURE COMMUNICATIONS,2016,7.
APA	Zhang, Rong-wei,Li, Xiao-quan,Kawakami, Koichi,&Du, Jiu-lin.(2016).Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors.NATURE COMMUNICATIONS,7.
MLA	Zhang, Rong-wei,et al."Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors".NATURE COMMUNICATIONS 7(2016).