ShanghaiTech University Knowledge Management System
SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling | |
Koledova, Zuzana1,2,3,4; Zhang, Xiaohong1,2; Streuli, Charles1,2; Clarke, Robert B.5; Klein, Ophir D.6,7,8,9; Werb, Zena10; Lu, Pengfei4 | |
2016-09-27 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8424 |
卷号 | 113期号:39页码:E5731-E5740 |
发表状态 | 已发表 |
DOI | 10.1073/pnas.1611532113 |
摘要 | The role of the local microenvironment in influencing cell behavior is central to both normal development and cancer formation. Here, we show that sprouty 1 (SPRY1) modulates the microenvironment to enable proper mammary branching morphogenesis. This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. Loss of SPRY1 resulted in up-regulation of EGFR-extracellular signal-regulated kinase (ERK) signaling in response to amphiregulin and transforming growth factor alpha stimulation. Consequently, stromal paracrine signaling and ECM remodeling is augmented, leading to increased epithelial branching in themutant gland. By contrast, down-regulation of EGFR-ERK signaling due to gain of Sprouty function in the stroma led to stunted epithelial branching. Taken together, our results show that modulation of stromal paracrine signaling and ECM remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development. |
关键词 | branching morphogenesis FGF signaling EGF signaling epithelial-stromal interactions stromal microenvironment |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Medical Research Council[MR/L011840/1] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000383954700006 |
出版者 | NATL ACAD SCIENCES |
WOS关键词 | GROWTH-FACTOR RECEPTOR ; BRANCHING MORPHOGENESIS ; EXTRACELLULAR-MATRIX ; DISTINCT ROLES ; BREAST-CANCER ; IGF-I ; GLAND ; FGF ; GENE ; DIFFERENTIATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1701 |
专题 | 生命科学与技术学院_PI研究组_吕鹏飞组 |
通讯作者 | Werb, Zena; Lu, Pengfei |
作者单位 | 1.Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England 2.Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England 3.Masaryk Univ, Fac Med, Dept Histol & Embryol, Brno 62500, Czech Republic 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Manchester, Inst Canc Sci, Breast Canc Now Res Unit, Manchester Canc Res Ctr, Manchester M20 4QL, Lancs, England 6.Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94143 USA 7.Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA 8.Univ Calif San Francisco, Program Craniofacial Biol, San Francisco, CA 94143 USA 9.Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA 10.Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Koledova, Zuzana,Zhang, Xiaohong,Streuli, Charles,et al. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(39):E5731-E5740. |
APA | Koledova, Zuzana.,Zhang, Xiaohong.,Streuli, Charles.,Clarke, Robert B..,Klein, Ophir D..,...&Lu, Pengfei.(2016).SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(39),E5731-E5740. |
MLA | Koledova, Zuzana,et al."SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.39(2016):E5731-E5740. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。