Acquiring new memories in neocortex of hippocampal-lesioned mice

doi:10.1038/s41467-022-29208-5

	Acquiring new memories in neocortex of hippocampal-lesioned mice
	Luo, Wenhan1 ; Yun, Di1 ; Hu, Yi 1; Tian, Miaomiao 1; Yang, Jiajun 2; Xu, Yifan 2; Tang, Yong 3; Zhan, Yang 3; Xie, Hong 4,5; Guan, Ji Song1,6
	2022-03-24
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-29208-5
摘要	["Hippocampal lesioned mice form new memories. Here, the authors show the lateral entorhinal cortex modulates learning-induced cortical long-range gamma synchrony in a hippocampal-dependent manner and artificially induced cortical gamma synchrony across cortical areas improved memory encoding in hippocampal lesioned mice.","The hippocampus interacts with the neocortical network for memory retrieval and consolidation. Here, we found the lateral entorhinal cortex (LEC) modulates learning-induced cortical long-range gamma synchrony (20-40 Hz) in a hippocampal-dependent manner. The long-range gamma synchrony, which was coupled to the theta (7-10 Hz) rhythm and enhanced upon learning and recall, was mediated by inter-cortical projections from layer 5 neurons of the LEC to layer 2 neurons of the sensory and association cortices. Artificially induced cortical gamma synchrony across cortical areas improved memory encoding in hippocampal lesioned mice for originally hippocampal-dependent tasks. Mechanistically, we found that activities of cortical c-Fos labeled neurons, which showed egocentric map properties, were modulated by LEC-mediated gamma synchrony during memory recall, implicating a role of cortical synchrony to generate an integrative memory representation from disperse features. Our findings reveal the hippocampal mediated organization of cortical memories and suggest brain-machine interface approaches to improve cognitive function."]
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Science & Technology Innovation 2030 Project of China[2021ZD0203500] ; NSFC[31970903,31671104,31371059] ; Shanghai ministry of science and technology[19ZR1477400] ; STCSM[18JC1420301] ; NSFC/DGF TRR-169[61621136008]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000773001900024
出版者	NATURE PORTFOLIO
Scopus 记录号	2-s2.0-85127029292
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/169244
专题	生命科学与技术学院_PI研究组_管吉松组
作者单位	1.School of Life Science and Technology,Shanghai Tech University,Shanghai,201210,China 2.School of Life Sciences,Tsinghua University,Beijing,100084,China 3.Brain Cognition and Brain Disease Institute,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China 4.Institute of Photonic Chips,University of Shanghai for Science and Technology,Shanghai,200093,China 5.Centre for Artificial-Intelligence Nanophotonics,School of Optical-Electrical and Computer Engineering,University of Shanghai for Science and Technology,Shanghai,China 6.CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai,200031,China
第一作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Luo, Wenhan,Yun, Di,Hu, Yi,et al. Acquiring new memories in neocortex of hippocampal-lesioned mice[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Luo, Wenhan.,Yun, Di.,Hu, Yi.,Tian, Miaomiao.,Yang, Jiajun.,...&Guan, Ji Song.(2022).Acquiring new memories in neocortex of hippocampal-lesioned mice.NATURE COMMUNICATIONS,13(1).
MLA	Luo, Wenhan,et al."Acquiring new memories in neocortex of hippocampal-lesioned mice".NATURE COMMUNICATIONS 13.1(2022).