Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins

doi:10.3389/fcell.2022.827940

	Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins
	Shum, Winnie1,2 ; Zhang, Bao Li1,2,3 ; Cao, Albert Shang1 ; Zhou, Xin1 ; Shi, Su Meng1 ; Zhang, Ze Yang1 ; Gu, Lou Yi1 ; Shi, Shuo4
	2022-02-17
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (IF:4.6[JCR-2023],5.2[5-Year])
ISSN	2296-634X
卷号	10
发表状态	已发表
DOI	10.3389/fcell.2022.827940
摘要	In the male reproductive tract, the epididymis is an essential organ for sperm maturation, in which sperm cells acquire mobility and the ability to fertilize oocytes while being stored in a protective microenvironment. Epididymal function involves a specialized luminal microenvironment established by the epithelial cells of epididymal mucosa. Low-calcium concentration is a unique feature of this epididymal luminal microenvironment, its relevance and regulation are, however, incompletely understood. In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation. An SNP in the human GGCX gene has been associated with asthenozoospermia. In addition, bioinformatic analysis also suggests the involvement of a vitamin B6-axis in calcium-dependent MGP-mediated protein aggregation. These findings suggest that vitamins interact with calcium homeostasis in the epididymis to ensure proper sperm maturation and male fertility. This review article discusses the regulation mechanisms of calcium homeostasis in the epididymis, and the potential role of vitamin interactions on epididymal calcium homeostasis, especially the role of matrix calcium in the epididymal lumen as a cofactor for the carboxylated MGP-mediated scavenging function.
关键词	sperm maturation epididymis calcium homeostasis luminal microenvironment GGCX matrix gla protein (MGP) Trpv6 Tmem16a
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	NNSFC[31871166,82071704]
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
WOS记录号	WOS:000772058100001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/169228
专题	生命科学与技术学院_本科生生命科学与技术学院_PI研究组_岑慧枝组免疫化学研究所_特聘教授组_干细胞生物学实验室生命科学与技术学院_硕士生生命科学与技术学院_博士生
通讯作者	Shum, Winnie
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China 3.Fudan Univ, Reprod & Dev Inst, Shanghai Inst Biomed & Pharmaceut Technol, NHC Key Lab Reprod Regulat, Shanghai, Peoples R China 4.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Shum, Winnie,Zhang, Bao Li,Cao, Albert Shang,et al. Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10.
APA	Shum, Winnie.,Zhang, Bao Li.,Cao, Albert Shang.,Zhou, Xin.,Shi, Su Meng.,...&Shi, Shuo.(2022).Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10.
MLA	Shum, Winnie,et al."Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022).