Antigen Receptor Nanoclusters: Small Units with Big Functions

doi:10.1016/j.it.2016.07.007

	Antigen Receptor Nanoclusters: Small Units with Big Functions
	Liu, Wanli 1; Wang, Haopeng2 ; Xu, Chenqi2,3
	2016-10
发表期刊	TRENDS IN IMMUNOLOGY (IF:13.1[JCR-2023],16.0[5-Year])
ISSN	1471-4906
卷号	37 期号:10 页码:680-689
发表状态	已发表
DOI	10.1016/j.it.2016.07.007
摘要	Adaptive lymphocytes express highly variable antigen receptors, allowing them to recognize a large variety of proteins, for example, derived from pathogens and tumor cells. Despite decades of investigations, the signaling mechanisms of these receptors are still incompletely understood. Super-resolution imaging studies revealed that antigen receptors, their coreceptors, and even some downstream signaling molecules tend to form dynamic nanometers-sized self-clusters in quiescent cells. Antigen stimulation induces the coalescence of these nanoclusters to form membrane proximal signalosomes that can mediate efficient signal transduction. In this review, we discuss the dynamic structures of T cell receptor and B cell receptor nanoclusters, the driving forces behind this spatial reorganization, as well as their potential relevance in the modulation of lymphocyte activation and function.
收录类别	SCI
语种	英语
资助项目	CAS Strategic Priority Research Program[XDB08020100]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000385322100006
出版者	ELSEVIER SCI LTD
WOS关键词	T-CELL-RECEPTOR ; MEMORY B-CELLS ; PLASMA-MEMBRANE ; IMMUNOLOGICAL SYNAPSE ; CYTOPLASMIC DOMAIN ; SUBUNIT CONTAINS ; BINDING MOTIF ; ACTIVATION ; TCR ; MICROCLUSTERS
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1690
专题	生命科学与技术学院_特聘教授组_许琛琦组生命科学与技术学院_PI研究组_王皞鹏组
通讯作者	Liu, Wanli; Xu, Chenqi
作者单位	1.Tsinghua Univ, Sch Life Sci, MOE Key Lab Prot Sci, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Sci Res Ctr,Inst Biochem & Cell Biol, State Key Lab Mol Biol,Natl Ctr Prot Sci Shanghai, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Wanli,Wang, Haopeng,Xu, Chenqi. Antigen Receptor Nanoclusters: Small Units with Big Functions[J]. TRENDS IN IMMUNOLOGY,2016,37(10):680-689.
APA	Liu, Wanli,Wang, Haopeng,&Xu, Chenqi.(2016).Antigen Receptor Nanoclusters: Small Units with Big Functions.TRENDS IN IMMUNOLOGY,37(10),680-689.
MLA	Liu, Wanli,et al."Antigen Receptor Nanoclusters: Small Units with Big Functions".TRENDS IN IMMUNOLOGY 37.10(2016):680-689.