Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons

doi:10.1111/ejn.15626

	Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons
	Chen, Qi-Nan1,2,3 ; Ding, Xin-Lu 1; Guo, Xiu-Xian1 ; Zhou, Gang1 ; Guan, Ji-Song1,4
	2022-03
发表期刊	EUROPEAN JOURNAL OF NEUROSCIENCE (IF:2.7[JCR-2023],3.2[5-Year])
ISSN	0953-816X
EISSN	1460-9568
发表状态	已发表
DOI	10.1111/ejn.15626
摘要	Adult newborn neurons are involved in memory encoding and extinction, but the neural mechanism is unclear. We found the adult newborn neurons at 4 weeks are recruited by learning and subjected to epigenetic regulations, consequently reducing their ability to be re-recruited later. After removal of the epigenetic blockage, Suv39h1 KO mice showed an increased recruiting number of aged newborn neurons and enhanced flexibility in learning tasks. Besides NRXN1, we found SHANK1, the synaptic scaffold protein, is one of the major targets of Suv39h1, regulating memory stability. Expression of Shank1 is transiently engaged to enhance synaptogenesis during learning and is strongly suppressed by Suv39h1 from 5 h after learning. Exogenously overexpression of Shank1 in dentate gyrus increased the density of mushroom spines and decreased the persistency of old memories. Our study indicated the activity-regulated epigenetic modification in newly matured newborn neurons in hippocampus insulates temporally distinct experiences and stabilizes old memories.
关键词	epigenetic modification memory stability newborn neuron Shank1 Suv39h1
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Science & Technology Innovation 2030 major project of China[2021ZD0203500] ; National Natural Science Foundation of China[31970903,31671104,31371059,61621136008] ; Shanghai Ministry of Science and Technology[19ZR1477400] ; German Research Foundation (DFG) in project Crossmodal Learning[DGF TRR-169]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000766068900001
出版者	WILEY
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/165021
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_管吉松组生命科学与技术学院_硕士生
通讯作者	Guan, Ji-Song
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Qi-Nan,Ding, Xin-Lu,Guo, Xiu-Xian,et al. Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2022.
APA	Chen, Qi-Nan,Ding, Xin-Lu,Guo, Xiu-Xian,Zhou, Gang,&Guan, Ji-Song.(2022).Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.EUROPEAN JOURNAL OF NEUROSCIENCE.
MLA	Chen, Qi-Nan,et al."Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons".EUROPEAN JOURNAL OF NEUROSCIENCE (2022).