Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences

doi:10.3389/fendo.2022.844351

	Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences
	Zhang, Ming 1; Li, Zhihui 2; Wang, Hanqi 2; Chen, Tongtong 2; Lu, Yong 2; Yan, Fuhua 2; Zhang, Yuyao3 ; Wei, Hongjiang 1
	2022-02-22
发表期刊	FRONTIERS IN ENDOCRINOLOGY (IF:3.9[JCR-2023],4.9[5-Year])
ISSN	1664-2392
卷号	13
发表状态	已发表
DOI	10.3389/fendo.2022.844351
摘要	BackgroundIt is of great clinical importance to assess the microstructure of the articular cartilage and cortical bone of the human knee joint. While quantitative susceptibility mapping (QSM) is a promising tool for investigating the knee joint, however, previous QSM studies using conventional gradient recalled echo sequences or ultrashort echo time (UTE) sequences only focused on mapping the magnetic susceptibility of the articular cartilage or cortical bone, respectively. Simultaneously mapping the underlying susceptibilities of the articular cartilage and cortical bone of human in vivo has not been explored and reported. MethodThree-dimensional multi-echo radial UTE sequences with the shortest TE of 0.07 msec and computed tomography (CT) were performed on the bilateral knee joints of five healthy volunteers for this prospective study. UTE-QSM was reconstructed from the local field map after water-fat separation and background field removal. Spearman's correlation analysis was used to explore the relationship between the magnetic susceptibility and CT values in 158 representative regions of interest of cortical bone. ResultThe susceptibility properties of the articular cartilage and cortical bone were successfully quantified by UTE-QSM. The laminar structure of articular cartilage was characterized by the difference of susceptibility value in each layer. Susceptibility was mostly diamagnetic in cortical bone. A significant negative correlation (r=-0.43, p<0.001) between the susceptibility value and CT value in cortical bone was observed. ConclusionUTE-QSM enables simultaneous susceptibility mapping of the articular cartilage and cortical bone of human in vivo. Good association between susceptibility and CT values in cortical bone suggests the potential of UTE-QSM for bone mapping for further clinical application.
关键词	quantitative susceptibility mapping ultrashort echo time articular cartilage cortical bone computed tomography
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收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000769786600001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/165003
专题	生物医学工程学院信息科学与技术学院_PI研究组_张玉瑶组
通讯作者	Wei, Hongjiang
作者单位	1.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiol, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Informat & Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ming,Li, Zhihui,Wang, Hanqi,et al. Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13.
APA	Zhang, Ming.,Li, Zhihui.,Wang, Hanqi.,Chen, Tongtong.,Lu, Yong.,...&Wei, Hongjiang.(2022).Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences.FRONTIERS IN ENDOCRINOLOGY,13.
MLA	Zhang, Ming,et al."Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences".FRONTIERS IN ENDOCRINOLOGY 13(2022).