Mfsd2a(+) hepatocytes repopulate the liver during injury and regeneration

doi:10.1038/ncomms13369

	Mfsd2a(+) hepatocytes repopulate the liver during injury and regeneration
	Pu, Wenjuan 1,2; Zhang, Hui 1,2; Huang, Xiuzhen 1,2; Tian, Xueying 1,2; He, Lingjuan 1,2; Wang, Yue 1,2; Zhang, Libo 1,2; Liu, Qiaozhen 1,2; Li, Yan 1,2; Li, Yi 1,2; Zhao, Huan 1,2; Liu, Kuo 1; Lu, Jie 3; Zhou, Yingqun 3; Huang, Pengyu4 ; Nie, Yu 5,6; Yan, Yan 7; Hui, Lijian2,4 ; Lui, Kathy O.8; Zhou, Bin1,2,4,9,10
	2016-11-18
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN	2041-1723
卷号	7
发表状态	已发表
DOI	10.1038/ncomms13369
摘要	Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes. During liver injury and regeneration, the cellular dynamics of these two distinct populations remain largely elusive. Here we show that major facilitator super family domain containing 2a (Mfsd2a), previously known to maintain blood-brain barrier function, is a periportal zonation marker. By genetic lineage tracing of Mfsd2a(+) periportal hepatocytes, we show that Mfsd2a(+) population decreases during liver homeostasis. Nevertheless, liver regeneration induced by partial hepatectomy significantly stimulates expansion of the Mfsd2a(+) periportal hepatocytes. Similarly, during chronic liver injury, the Mfsd2a(+) hepatocyte population expands and completely replaces the pericentral hepatocyte population throughout the whole liver. After injury recovery, the adult liver re-establishes the metabolic zonation by reprogramming the Mfsd2a(+)-derived hepatocytes into pericentral hepatocytes. The evidence of entire zonation replacement during injury increases our understanding of liver biology and disease.
收录类别	SCI
语种	英语
资助项目	Shanghai Zhangjiang Stem Cell Research Project[ZJ2014-ZD-002]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000387990500001
出版者	NATURE PUBLISHING GROUP
WOS关键词	MATURE HEPATOCYTES ; MOUSE HEPATOCYTES ; GENE-EXPRESSION ; ZONATION ; CELLS ; HOMEOSTASIS ; MECHANISM ; OCCURS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1636
专题	生命科学与技术学院_特聘教授组_惠利健组生命科学与技术学院_PI研究组_黄鹏羽组生命科学与技术学院_特聘教授组_周斌组
通讯作者	Zhou, Bin
作者单位	1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Yueyang Rd 320,A2112, Shanghai 200031, Peoples R China 3.Tongji Univ, Sch Med, Dept Gastroenterol, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China 6.Peking Union Med Coll, Beijing 100037, Peoples R China 7.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China 8.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Dept Chem Pathol, Shatin 999077, Hong Kong, Peoples R China 9.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China 10.Jinan Univ, Inst Aging & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Guangdong, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Pu, Wenjuan,Zhang, Hui,Huang, Xiuzhen,et al. Mfsd2a(+) hepatocytes repopulate the liver during injury and regeneration[J]. NATURE COMMUNICATIONS,2016,7.
APA	Pu, Wenjuan.,Zhang, Hui.,Huang, Xiuzhen.,Tian, Xueying.,He, Lingjuan.,...&Zhou, Bin.(2016).Mfsd2a(+) hepatocytes repopulate the liver during injury and regeneration.NATURE COMMUNICATIONS,7.
MLA	Pu, Wenjuan,et al."Mfsd2a(+) hepatocytes repopulate the liver during injury and regeneration".NATURE COMMUNICATIONS 7(2016).