A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification
Guo, Wei-Feng1; Zhang, Shao-Wu1; Shi, Qian-Qian2; Zhang, Cheng-Ming2; Zeng, Tao2; Chen, Luonan1,2,3
2018-01-19
Source PublicationBMC GENOMICS
ISSN1471-2164
Volume19
DOI10.1186/s12864-017-4332-z
AbstractBackground: The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic targets for disease intervention. In many cases, e.g. drug target identification in biological networks, we usually require a target control on a subset of nodes (i.e., disease-associated genes) with minimum cost, and we further expect that more driver nodes consistent with a certain well-selected network nodes (i.e., prior-known drug-target genes).
KeywordTarget control Objectives-guided optimization Drug targets Dynamics of complex networks
Indexed BySCI ; CPCI
Language英语
Funding ProjectNatural Science Foundation of Shanghai[17ZR1446100]
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000422886100007
PublisherBMC
WOS KeywordCONTROLLABILITY ; SENSITIVITY ; BIOMARKERS ; RESISTANCE ; PROFILES ; GENES
Original Document TypeArticle ; Proceedings Paper
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16317
Collection生命科学与技术学院_特聘教授组_陈洛南组
Corresponding AuthorZhang, Shao-Wu; Zeng, Tao; Chen, Luonan
Affiliation1.Northwestern Polytech Univ, Sch Automat, Key Lab Informat Fus Technol, Minist Educ, Xian 710072, Shaanxi, Peoples R China
2.Univ Chinese Acad Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200000, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200000, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Guo, Wei-Feng,Zhang, Shao-Wu,Shi, Qian-Qian,et al. A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification[J]. BMC GENOMICS,2018,19.
APA Guo, Wei-Feng,Zhang, Shao-Wu,Shi, Qian-Qian,Zhang, Cheng-Ming,Zeng, Tao,&Chen, Luonan.(2018).A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification.BMC GENOMICS,19.
MLA Guo, Wei-Feng,et al."A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification".BMC GENOMICS 19(2018).
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