A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification

doi:10.1186/s12864-017-4332-z

	A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification
	Guo, Wei-Feng 1; Zhang, Shao-Wu 1; Shi, Qian-Qian 2; Zhang, Cheng-Ming 2; Zeng, Tao 2; Chen, Luonan1,2,3
	2018-01-19
发表期刊	BMC GENOMICS
ISSN	1471-2164
卷号	19
发表状态	已发表
DOI	10.1186/s12864-017-4332-z
摘要	Background: The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic targets for disease intervention. In many cases, e.g. drug target identification in biological networks, we usually require a target control on a subset of nodes (i.e., disease-associated genes) with minimum cost, and we further expect that more driver nodes consistent with a certain well-selected network nodes (i.e., prior-known drug-target genes).
关键词	Target control Objectives-guided optimization Drug targets Dynamics of complex networks
收录类别	SCI ; SCIE ; CPCI
语种	英语
资助项目	Natural Science Foundation of Shanghai[17ZR1446100]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000422886100007
出版者	BMC
WOS关键词	CONTROLLABILITY ; SENSITIVITY ; BIOMARKERS ; RESISTANCE ; PROFILES ; GENES
原始文献类型	Article ; Proceedings Paper
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16317
专题	生命科学与技术学院_特聘教授组_陈洛南组
通讯作者	Zhang, Shao-Wu; Zeng, Tao; Chen, Luonan
作者单位	1.Northwestern Polytech Univ, Sch Automat, Key Lab Informat Fus Technol, Minist Educ, Xian 710072, Shaanxi, Peoples R China 2.Univ Chinese Acad Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200000, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200000, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Guo, Wei-Feng,Zhang, Shao-Wu,Shi, Qian-Qian,et al. A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification[J]. BMC GENOMICS,2018,19.
APA	Guo, Wei-Feng,Zhang, Shao-Wu,Shi, Qian-Qian,Zhang, Cheng-Ming,Zeng, Tao,&Chen, Luonan.(2018).A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification.BMC GENOMICS,19.
MLA	Guo, Wei-Feng,et al."A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification".BMC GENOMICS 19(2018).