Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future

doi:10.3233/JPD-212976

	Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future
	Tan, Yu-Yan 1,2; Jenner, Peter 3; Chen, Sheng-Di1,2,4
	2022
发表期刊	JOURNAL OF PARKINSONS DISEASE (IF:4.0[JCR-2023],4.8[5-Year])
ISSN	1877-7171
EISSN	1877-718X
卷号	12 期号:2
发表状态	已发表
DOI	10.3233/JPD-212976
摘要	Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson's disease (PD). MAO-B inhibitor monotherapy has been shown to be effective and safe for the treatment of early-stage PD, while MAO-B inhibitors as adjuvant drugs have been widely applied for the treatment of the advanced stages of the illness. MAO-B inhibitors can effectively improve patients' motor and non-motor symptoms, reduce "OFF" time, and may potentially prevent/delay disease progression. In this review, we discuss the effects of MAO-B inhibitors on motor and non-motor symptoms in PD patients, their mechanism of action, and the future development of MAO-B inhibitor therapy.
关键词	Monoamine oxidase-B inhibitors Parkinson's disease selegiline rasagiline safinamide
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000759160900001
出版者	IOS PRESS
引用统计	被引频次：130[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/162925
专题	免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Chen, Sheng-Di
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Inst Neurol, Shanghai, Peoples R China 3.Kings Coll London, Fac Hlth Sci & Med, Inst Pharmaceut Sci, Neurodegenerat Dis Res Grp, London, England 4.Shanghai Tech Univ, Inst Immunochem, Lab Translat Res Neurodegenerat Dis, Shanghai, Peoples R China
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Tan, Yu-Yan,Jenner, Peter,Chen, Sheng-Di. Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future[J]. JOURNAL OF PARKINSONS DISEASE,2022,12(2).
APA	Tan, Yu-Yan,Jenner, Peter,&Chen, Sheng-Di.(2022).Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future.JOURNAL OF PARKINSONS DISEASE,12(2).
MLA	Tan, Yu-Yan,et al."Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future".JOURNAL OF PARKINSONS DISEASE 12.2(2022).