Targeting IRF3 as a YAP agonist therapy against gastric cancer
Jiao, Shi1; Guan, Jingmin1; Chen, Min1; Wang, Wenjia1; Li, Chuanchuan1; Wang, Yugong2; Cheng, Yunfeng3,4; Zhou, Zhaocai1,2
2018-02
Source PublicationJOURNAL OF EXPERIMENTAL MEDICINE
ISSN0022-1007
Volume215Issue:2Pages:699-718
Status已发表
DOI10.1084/jem.20171116
AbstractThe Hippo pathway plays a vital role in tissue homeostasis and tumorigenesis. The transcription factor IRF3 is essential for innate antiviral immunity. In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the expression of both IRF3 and YAP is up-regulated and prognosticates patient survival. IRF3 interacts with both YAP and TEAD4 in the nucleus to enhance their interaction, promoting nuclear translocation and activation of YAP. IRF3 and YAP-TEAD4 are associated genome-wide to cobind and coregulate many target genes of the Hippo pathway. Overexpression of active IRF3 increased, but depletion of IRF3 reduced, the occupancy of YAP on the target genes. Knockdown or pharmacological targeting of IRF3 by Amlexanox, a drug used clinically for antiinflammatory treatment, inhibits gastric tumor growth in a YAP-dependent manner. Collectively, our study identifies IRF3 as a positive regulator for YAP, highlighting a new therapeutic target against YAP-driven cancers.
Indexed BySCI
Language英语
Funding ProjectScience and Technology Commission of Shanghai Municipality[17YF1422200] ; Science and Technology Commission of Shanghai Municipality[17ZR1435400]
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
WOS IDWOS:000424519300021
PublisherROCKEFELLER UNIV PRESS
WOS KeywordHIPPO SIGNALING PATHWAY ; ORGAN SIZE CONTROL ; INTERFERON REGULATORY FACTOR-3 ; MINOR APHTHOUS ULCERATION ; CELL CONTACT INHIBITION ; TUMOR-SUPPRESSOR ; INNATE IMMUNITY ; GROWTH-CONTROL ; INTESTINAL REGENERATION ; COLORECTAL-CANCER
Original Document TypeArticle
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16272
Collection生命科学与技术学院
生命科学与技术学院_特聘教授组_周兆才组
生命科学与技术学院_硕士生
Corresponding AuthorJiao, Shi; Zhou, Zhaocai
Affiliation1.Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol,Shanghai Inst B, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Fudan Univ, Dept Hematol, Zhongshan Hosp, Shanghai, Peoples R China
4.Fudan Univ, Inst Clin Sci, Zhongshan Hosp, Shanghai, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Jiao, Shi,Guan, Jingmin,Chen, Min,et al. Targeting IRF3 as a YAP agonist therapy against gastric cancer[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(2):699-718.
APA Jiao, Shi.,Guan, Jingmin.,Chen, Min.,Wang, Wenjia.,Li, Chuanchuan.,...&Zhou, Zhaocai.(2018).Targeting IRF3 as a YAP agonist therapy against gastric cancer.JOURNAL OF EXPERIMENTAL MEDICINE,215(2),699-718.
MLA Jiao, Shi,et al."Targeting IRF3 as a YAP agonist therapy against gastric cancer".JOURNAL OF EXPERIMENTAL MEDICINE 215.2(2018):699-718.
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