Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces; Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces
Fu, Ruxing1,2; Luo, Wenhan3,4,5; Nazempour, Roya1; Tan, Daxin2; Ding, He1; Zhang, Kaiyuan1,2; Yin, Lan2; Guan, Jisong5,6; Sheng, Xing1
2018-02-05 ; 2018-02-05
Source PublicationADVANCED OPTICAL MATERIALS ; ADVANCED OPTICAL MATERIALS
ISSN2195-1071 ; 2195-1071
Volume6Issue:3
Status已发表 ; 已发表
DOI10.1002/adom.201700941 ; 10.1002/adom.201700941
AbstractAdvanced optical fibers and photonic structures play important roles in neuroscience research, along with recent progresses of genetically encoded optical actuators and indicators. Most techniques for optical neural implants rely on fused silica or long-lasting polymeric fiber structures. In this paper, implantable and biodegradable optical fibers based on poly(l-lactic acid) (PLLA) are presented. PLLA fibers with dimensions similar to standard silica fibers are constructed using a simple thermal drawing process at around 220 degrees C. The formed PLLA fibers exhibit high mechanical flexibility and optical transparency, and their structural evolution and optical property changes are systematically studied during in vitro degradation. In addition, their biocompatibility with brain tissues is evaluated in living mice, and full in vivo degradation is demonstrated. Finally, PLLA fibers are implemented as a tool for intracranial light delivery and detection, realizing deep brain fluorescence sensing and optogenetic interrogation in vivo. The presented materials and device platform offer paths to fully biocompatible and bioresorbable photonic systems for biomedical uses.; Advanced optical fibers and photonic structures play important roles in neuroscience research, along with recent progresses of genetically encoded optical actuators and indicators. Most techniques for optical neural implants rely on fused silica or long-lasting polymeric fiber structures. In this paper, implantable and biodegradable optical fibers based on poly(l-lactic acid) (PLLA) are presented. PLLA fibers with dimensions similar to standard silica fibers are constructed using a simple thermal drawing process at around 220 degrees C. The formed PLLA fibers exhibit high mechanical flexibility and optical transparency, and their structural evolution and optical property changes are systematically studied during in vitro degradation. In addition, their biocompatibility with brain tissues is evaluated in living mice, and full in vivo degradation is demonstrated. Finally, PLLA fibers are implemented as a tool for intracranial light delivery and detection, realizing deep brain fluorescence sensing and optogenetic interrogation in vivo. The presented materials and device platform offer paths to fully biocompatible and bioresorbable photonic systems for biomedical uses.
Keywordbiodegradable devices biodegradable devices fluorescence detection fluorescence detection implantable devices implantable devices optical fibers optical fibers optogenetics optogenetics
Indexed BySCI ; SCI ; EI ; EI
Language英语 ; 英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[51602172] ; National Natural Science Foundation of China (NSFC)[51602172] ; National Natural Science Foundation of China (NSFC)[51601103] ; National Natural Science Foundation of China (NSFC)[51601103]
WOS Research AreaMaterials Science ; Materials Science ; Optics ; Optics
WOS SubjectMaterials Science, Multidisciplinary ; Materials Science, Multidisciplinary ; Optics ; Optics
WOS IDWOS:000424153300008 ; WOS:000424153300008
PublisherWILEY-V C H VERLAG GMBH ; WILEY-V C H VERLAG GMBH
EI Accession Number20180604770392 ; 20180604770392
EI KeywordsBiocompatibility ; Biocompatibility ; Biodegradation ; Biodegradation ; Biological materials ; Biological materials ; Fibers ; Fibers ; Fluorescence ; Fluorescence ; Fused silica ; Fused silica ; Implants (surgical) ; Implants (surgical) ; Lactic acid ; Lactic acid ; Optical fibers ; Optical fibers ; Optical properties ; Optical properties ; Silica ; Silica
EI Classification NumberBioengineering and Biology:461 ; Bioengineering and Biology:461 ; Prosthetics:462.4 ; Prosthetics:462.4 ; Light/Optics:741.1 ; Light/Optics:741.1 ; Fiber Optics:741.1.2 ; Fiber Optics:741.1.2 ; Organic Compounds:804.1 ; Organic Compounds:804.1 ; Glass:812.3 ; Glass:812.3
WOS KeywordHYDROLYTIC DEGRADATION ; HYDROLYTIC DEGRADATION ; REACTIVE GLIOSIS ; REACTIVE GLIOSIS ; WAVE-GUIDES ; WAVE-GUIDES ; IN-VIVO ; IN-VIVO ; KINETICS ; KINETICS ; BRAIN ; BRAIN ; OPTOGENETICS ; OPTOGENETICS ; POLYLACTIDES ; POLYLACTIDES ; ELECTRONICS ; ELECTRONICS ; HYDROGELS ; HYDROGELS
Original Document TypeArticle ; Article
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16235
Collection生命科学与技术学院_PI研究组_管吉松组
Corresponding AuthorGuan, Jisong; Sheng, Xing
Affiliation1.Tsinghua Univ, TNList, Dept Elect Engn, Beijing 100084, Peoples R China
2.Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
5.Tsinghua Univ, Sch Life Sci, IDG McGovern Inst Brain Res Tsinghua, MOE Key Lab Prot Sci,Ctr Brain Inspired Comp, Beijing 100084, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Fu, Ruxing,Luo, Wenhan,Nazempour, Roya,et al. Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces, Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces[J]. ADVANCED OPTICAL MATERIALS, ADVANCED OPTICAL MATERIALS,2018, 2018,6, 6(3).
APA Fu, Ruxing.,Luo, Wenhan.,Nazempour, Roya.,Tan, Daxin.,Ding, He.,...&Sheng, Xing.(2018).Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces.ADVANCED OPTICAL MATERIALS,6(3).
MLA Fu, Ruxing,et al."Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces".ADVANCED OPTICAL MATERIALS 6.3(2018).
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