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| Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease | |
| 2017-11-14 | |
| 发表期刊 | ONCOTARGET
 |
| ISSN | 1949-2553 |
| 卷号 | 8期号:57页码:97206-97216 |
| 发表状态 | 已发表 |
| DOI | 10.18632/oncotarget.21692 |
| 摘要 | Progressive renal fibrosis in chronic kidney disease (CKD) greatly contributes to end-stage renal failure and is associated with high mortality. The identification of renal fibrosis biomarkers for the diagnosis and the monitoring of disease progression in CKD is urgently needed. Whole-transcriptomic analysis of renal tissues in a unilateral ureteral obstruction (UUO) mouse model revealed that the mRNA level of Bcl-3, an atypical member of the NB family, was induced 6.3-fold 2 days after UUO. Compared with renal tissues in sham-operated mice, increases in Bcl-3 mRNA and protein in the renal tissues in the UUO model were accompanied with increases in other markers of renal fibrosis, including human epididymis protein 4 (HE4), a recently identified biomarker of renal fibrosis. Immunohistochemical analysis revealed that both Bcl-3 and HE4 were located in the plasma of renal tubule cells. Serum protein levels of Bcl-3 and HE4 rose with the development of renal fibrosis in UUO mouse model. We found that the serum protein levels of both HE4 and Bcl-3 were elevated in CKD patients compared with healthy controls. Moreover, a significant positive correlation between Bcl-3 and HE4 (r = 0.939, p < 0.0001) was observed in CKD patients. These data suggest that Bcl-3 can serve as a novel valuable biomarker of renal fibrosis in CKD. |
| 关键词 | Bcl-3 renal fibrosis chronic kidney disease unilateral ureteral obstruction biomarker |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31570902] ; National Natural Science Foundation of China[31370881] |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| WOS记录号 | WOS:000419395000069 |
| 出版者 | IMPACT JOURNALS LLC |
| WOS关键词 | CANDIDATE PROTOONCOGENE BCL-3 ; KAPPA-B ; OBSTRUCTIVE NEPHROPATHY ; URETERAL OBSTRUCTION ; ONCOPROTEIN BCL-3 ; P50 HOMODIMERS ; MOUSE MODEL ; INSIGHTS ; CANCER |
| 原始文献类型 | Article |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16216 |
| 专题 | 免疫化学研究所_特聘教授组_干细胞生物学实验室 |
| 通讯作者 | Li, Xuemei; Zhang, Xiaoren |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Inst, Shanghai 200031, Peoples R China 2.Chinese Peoples Liberat Army 105th Hosp, Clin Lab Dept, Hefei 230001, Anhui, Peoples R China 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 4.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Tumor Immunol & Gene Therapy Ctr, Shanghai 200433, Peoples R China 5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Nephrol, Beijing 100723, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Ran,Wang, Lunshan,Liu, Sanhong,et al. Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease[J]. ONCOTARGET,2017,8(57):97206-97216. |
| APA | Chen, Ran.,Wang, Lunshan.,Liu, Sanhong.,Chen, Xi.,Hu, Yiming.,...&Zhang, Xiaoren.(2017).Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease.ONCOTARGET,8(57),97206-97216. |
| MLA | Chen, Ran,et al."Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease".ONCOTARGET 8.57(2017):97206-97216. |
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