TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae

doi:10.1038/nn.4416

	TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae
	Luo, Junjie 1,2,3; Shen, Wei L.3,4 ; Montell, Craig 1,2
	2017-01
发表期刊	NATURE NEUROSCIENCE (IF:21.2[JCR-2023],25.6[5-Year])
ISSN	1097-6256
卷号	20 期号:1 页码:34-41
发表状态	已发表
DOI	10.1038/nn.4416
摘要	Avoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature. These cellular and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature increase. We propose that larvae use low-threshold sensors in the brain to monitor rapid temperature increases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the temperature of the brain rises to dangerous levels.
收录类别	SCI
语种	英语
资助项目	National Nature Science Foundation of China[X-0402-14-002]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000391085500010
出版者	NATURE PUBLISHING GROUP
WOS关键词	ION-CHANNEL TRPA1 ; RECEPTOR ; PAIN ; DISCRIMINATION ; CRISPR/CAS9 ; SENSITIVITY ; MECHANISMS ; NOCICEPTOR ; AVOIDANCE ; BEHAVIOR
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1581
专题	生命科学与技术学院_PI研究组_沈伟组
通讯作者	Montell, Craig
作者单位	1.Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA 2.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA 3.Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA 4.ShanghaiTech Univ, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Luo, Junjie,Shen, Wei L.,Montell, Craig. TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae[J]. NATURE NEUROSCIENCE,2017,20(1):34-41.
APA	Luo, Junjie,Shen, Wei L.,&Montell, Craig.(2017).TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.NATURE NEUROSCIENCE,20(1),34-41.
MLA	Luo, Junjie,et al."TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae".NATURE NEUROSCIENCE 20.1(2017):34-41.