Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates

doi:10.1161/CIRCRESAHA.121.320335

	Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates
	Tang, Juan 1; Zhu, Huan 1; Tian, Xueying 3; Wang, Haixiao 1; Liu, Shaoyan 4; Liu, Kuo 1; Zhao, Huan 1; He, Lingjuan 1; Huang, Xiuzhen 1; Feng, Zhao 5; Ding, Zhangheng 6; Long, Ben 7; Yan, Yan 4; Smart, Nicola 8; Gong, Hui 5,6; Luo, Qingming 7; Zhou, Bin1,2,9
	2022-02-04
发表期刊	CIRCULATION RESEARCH (IF:16.5[JCR-2023],20.3[5-Year])
ISSN	0009-7330
EISSN	1524-4571
卷号	130 期号:3
发表状态	已发表
DOI	10.1161/CIRCRESAHA.121.320335
摘要	Background: Unraveling how new coronary arteries develop may provide critical information for establishing novel therapeutic approaches to treating ischemic cardiac diseases. There are 2 distinct coronary vascular populations derived from different origins in the developing heart. Understanding the formation of coronary arteries may provide insights into new ways of promoting coronary artery formation after myocardial infarction. Methods: To understand how intramyocardial coronary arteries are generated to connect these 2 coronary vascular populations, we combined genetic lineage tracing, light sheet microscopy, fluorescence micro-optical sectioning tomography, and tissue-specific gene knockout approaches to understand their cellular and molecular mechanisms. Results: We show that a subset of intramyocardial coronary arteries form by angiogenic extension of endocardium-derived vascular tunnels in the neonatal heart. Three-dimensional whole-mount fluorescence imaging showed that these endocardium-derived vascular tunnels or tubes adopt an arterial fate in neonates. Mechanistically, we implicate Mettl3 (methyltransferase-like protein 3) and Notch signaling in regulating endocardium-derived intramyocardial coronary artery formation. Functionally, these intramyocardial arteries persist into adulthood and play a protective role after myocardial infarction. Conclusions: A subset of intramyocardial coronary arteries form by extension of endocardium-derived vascular tunnels in the neonatal heart.
关键词	arteries endocardium myocardial infarction population tomography
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Key Research and Development Program of China["2019YFA0110403","2019YFA0802000","2018YFA0107900","2018YFA0108100","2019YFA0802803","2020YFA0803202","2021YFA 0805100","2021YFA1101900"] ; National Natural Science Foundation of China[82088101,31625019,32050087,31730112,91849202,31801215,81872241,31922032,32070727,81827901,61890953,81872132] ; Shanghai Science and Technology Commission["19JC1415700","19ZR1479800"] ; Program for Guangdong Introduction Innovative and Entrepreneurial Teams[2017ZT07S347] ; BHF Ian Fleming Fellowship[FS/19/32/34376]
WOS研究方向	Cardiovascular System & Cardiology ; Hematology
WOS类目	Cardiac & Cardiovascular Systems ; Hematology ; Peripheral Vascular Disease
WOS记录号	WOS:000750283900009
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/154096
专题	生物医学工程学院生命科学与技术学院_特聘教授组_周斌组
通讯作者	Tang, Juan; Luo, Qingming; Zhou, Bin
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Beijing, Peoples R China 3.Jinan Univ, Coll Life Sci & Technol, Dept Dev & Regenerat Biol, Key Lab Regenerat Med,Minist Educ, Guangzhou, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China 5.JITRI, HUST Suzhou Inst Brainsmat, Suzhou, Peoples R China 6.Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, MoE Key Lab Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan, Peoples R China 7.Hainan Univ, Sch Biomed Engn, Key Lab Biomed Engn Hainan Prov, Haikou, Hainan, Peoples R China 8.Univ Oxford, British Heart Fdn Ctr Regenerat Med, Dept Physiol Anat & Genet, Oxford, England 9.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Tang, Juan,Zhu, Huan,Tian, Xueying,et al. Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates[J]. CIRCULATION RESEARCH,2022,130(3).
APA	Tang, Juan.,Zhu, Huan.,Tian, Xueying.,Wang, Haixiao.,Liu, Shaoyan.,...&Zhou, Bin.(2022).Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates.CIRCULATION RESEARCH,130(3).
MLA	Tang, Juan,et al."Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates".CIRCULATION RESEARCH 130.3(2022).