Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

doi:10.1007/s13238-016-0330-1

	Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance
	Xue, Yingjiao 1,2,3,5; Hou, Shenda 1,2,3,5; Ji, Hongbin1,2,3,4,5 ; Han, Xiangkun 1,2,3,5
	2017-03
发表期刊	PROTEIN & CELL (IF:13.6[JCR-2023],17.7[5-Year])
ISSN	1674-800X
卷号	8 期号:3 页码:178-190
发表状态	已发表
DOI	10.1007/s13238-016-0330-1
摘要	Lung cancer is the leading cause of cancer-related deaths worldwide. Targeted therapy is beneficial in most cases, but the development of drug resistance stands as an obstacle to good prognosis. Multiple mechanisms were explored such as genetic alterations, activation of bypass signaling, and phenotypic transition. These intrinsic and/or extrinsic dynamic regulations facilitate tumor cell survival in meeting the demands of signaling under different stimulus. This review introduces lung cancer plasticity and heterogeneity and their correlation with drug resistance. While cancer plasticity and heterogeneity play an essential role in the development of drug resistance, the manipulation of them may bring some inspirations to cancer prognosis and treatment. That is to say, lung cancer plasticity and heterogeneity present us with not only challenges but also opportunities.
关键词	lung cancer plasticity heterogeneity drug resistance phenotypic transition
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[15XD1504000]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000394991200005
出版者	SPRINGEROPEN
WOS关键词	CELL LUNG-CANCER ; GROWTH-FACTOR-RECEPTOR ; TYROSINE KINASE INHIBITORS ; EPITHELIAL-MESENCHYMAL TRANSITION ; TUMOR-INITIATING CELLS ; EGFR T790M MUTATION ; NONSMALL CELL ; ACQUIRED-RESISTANCE ; GEFITINIB RESISTANCE ; MET AMPLIFICATION
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1492
专题	生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Han, Xiangkun
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Xue, Yingjiao,Hou, Shenda,Ji, Hongbin,et al. Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance[J]. PROTEIN & CELL,2017,8(3):178-190.
APA	Xue, Yingjiao,Hou, Shenda,Ji, Hongbin,&Han, Xiangkun.(2017).Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance.PROTEIN & CELL,8(3),178-190.
MLA	Xue, Yingjiao,et al."Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance".PROTEIN & CELL 8.3(2017):178-190.