Characterising private and shared signatures of positive selection in 37 Asian populations

doi:10.1038/ejhg.2016.181

	Characterising private and shared signatures of positive selection in 37 Asian populations
	Liu, Xuanyao 1,2; Lu, Dongsheng 3,4; Saw, Woei-Yuh 2,5; Shaw, Philip J.6,7; Wangkumhang, Pongsakorn 6,7; Ngamphiw, Chumpol 6,7; Fucharoen, Suthat 8; Lert-itthiporn, Worachart 9,10; Chin-inmanu, Kwanrutai 10; Tran Nguyen Bich Chau 11; Anders, Katie 11,12; Kasturiratne, Anuradhani 13; de Silva, H. Janaka 14; Katsuya, Tomohiro 15; Kimura, Ryosuke 16; Nabika, Toru 17; Ohkubo, Takayoshi 18; Tabara, Yasuharu 19; Takeuchi, Fumihiko 20; Yamamoto, Ken 21; Yokota, Mitsuhiro 22; Mamatyusupu, Dolikun 23; Yang, Wenjun 24; Chung, Yeun-Jun 25; Jin, Li 26,27; Hoh, Boon-Peng 28; Wickremasinghe, Ananda R.13; Ong, RickTwee-Hee 2; Khor, Chiea-Chuen 29; Dunstan, Sarah J.30; Simmons, Cameron 31; Tongsima, Sissades 7; Suriyaphol, Prapat 32; Kato, Norihiro 20; Xu, Shuhua33,34 ; Teo, Yik-Ying 1,2,5,20,29,35
	2017-04
发表期刊	EUROPEAN JOURNAL OF HUMAN GENETICS (IF:3.7[JCR-2023],4.1[5-Year])
ISSN	1018-4813
卷号	25 期号:4 页码:499-508
发表状态	已发表
DOI	10.1038/ejhg.2016.181
摘要	The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple populations and observed that populations clustered in a similar fashion to that of how the ancestry clades were phylogenetically defined. In particular, populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Signatures of positive selection present in multiple geographical regions were predicted to be older and have emerged prior to the separation of the populations in the different regions. In contrast, selection signals present in a single population group tended to be of lower frequencies and thus can be attributed to recent evolutionary events.
收录类别	SCI
语种	英语
资助项目	Thailand Research Fund[RSA5860081]
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000395996200019
出版者	NATURE PUBLISHING GROUP
WOS关键词	HIGH-ALTITUDE ADAPTATION ; HUMAN GENETIC DIVERSITY ; RECENT HUMAN-EVOLUTION ; UNRELATED INDIVIDUALS ; SOUTHEAST-ASIA ; GENOME ; HISTORY ; SNP ; ASSOCIATION ; INFERENCE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1446
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Teo, Yik-Ying
作者单位	1.Natl Univ Singapore, INUS Grad Sch Integrat Sci & Engn, Singapore, Singapore 2.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, MD1,12 Sci Dr 2, Singapore 117549, Singapore 3.Chinese Acad Sci, Max Planck Independent Res Grp Populat Genom, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Soc Partner Inst Computat Biol, Shanghai, Peoples R China 5.Natl Univ Singapore, Inst Life Sci, Singapore, Singapore 6.Natl Ctr Genet Engn & Biotechnol, Natl Sci & Technol Dev Agcy, Pathum Thani, Thailand 7.Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Pathum Thani, Thailand 8.Mahidel Univ, Inst Mol Biosci, Nakhon Pathom, Thailand 9.Mahidol Univ, Fac Sci, Mol Med Grad Programme, Bangkok, Thailand 10.Mahidol Univ, Fac Med Siriraj Hosp, Dept Res & Dev, Div Bioinformat & Data Management Res, Bangkok, Thailand 11.Univ Oxford, Hosp Trop Dis, Clin Res Unit, Ho Chi Minh City, Vietnam 12.Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England 13.Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama, Sri Lanka 14.Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka 15.Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka, Japan 16.Univ Ryukyus, Grad Sch Med, Dept Human Biol & Anat, Nishihara, Okinawa, Japan 17.Shimane Univ, Sch Med, Dept Funct Pathol, Izumo, Shimane, Japan 18.Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan 19.Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan 20.Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Tokyo, Japan 21.Kurume Univ, Sch Med, Dept Med Chem, Kurume, Fukuoka, Japan 22.Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi, Japan 23.Xinjiang Univ, Coll Life Sci & Technol, Urumqi, Peoples R China 24.Ningxia Med Univ, Key Lab Reprod & Hered Ningxia Reg, Yinchuan, Peoples R China 25.Cathol Univ, Integrated Res Ctr Genome Polymorphism, Coll Med, Dept Microbiol, Seoul, South Korea 26.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China 27.Fudan Univ, Minist Educ, Sch Life Sci, Key Lab Contemporary Anthropol, Shanghai, Peoples R China 28.UCSI Univ, Fac Med & Hlth Sci, Kuala Lumpur, Malaysia 29.Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore 30.Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia 31.Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia 32.Mahidol Univ, Siriraj Hosp, Fac Med, Inst Personalized Genom & Gene Therapy IPGG, Bangkok, Thailand 33.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 34.Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China 35.Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore, Singapore
推荐引用方式 GB/T 7714	Liu, Xuanyao,Lu, Dongsheng,Saw, Woei-Yuh,et al. Characterising private and shared signatures of positive selection in 37 Asian populations[J]. EUROPEAN JOURNAL OF HUMAN GENETICS,2017,25(4):499-508.
APA	Liu, Xuanyao.,Lu, Dongsheng.,Saw, Woei-Yuh.,Shaw, Philip J..,Wangkumhang, Pongsakorn.,...&Teo, Yik-Ying.(2017).Characterising private and shared signatures of positive selection in 37 Asian populations.EUROPEAN JOURNAL OF HUMAN GENETICS,25(4),499-508.
MLA	Liu, Xuanyao,et al."Characterising private and shared signatures of positive selection in 37 Asian populations".EUROPEAN JOURNAL OF HUMAN GENETICS 25.4(2017):499-508.