Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation

doi:10.18632/oncotarget.19210

	Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation
	Cheng Yajun 1; Ye Chen 2; Li Xiaosa3 ; Wang Xiao3 ; Chen Jia3 ; Wang Zhong 1; Xu Bin 1
	2017-10-27
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	8 期号:52 页码:89620-89630
发表状态	已发表
DOI	10.18632/oncotarget.19210
摘要	The role of Sun2 has been described by previous studies in various types of cancers, including breast cancer and lung cancer. However, its role and potential molecular mechanism in the progression of prostate cancer have not been fully elucidated. In the present study, we found that Sun2 expression was reduced in prostate cancer tissues compared with paired normal tissues, and that low expression of Sun2 was significantly correlated with Higher Gleason scores, postoperative T stage (pT), Lymph nodal invasion and Clinical pathological stages. In addition, reduced Sun2 Expression predicts poor survival of prostate cancer patients and could serve as an independent predictor of prostate cancer patients overall survival (OS). Furthermore, Sun2 overexpression inhibits the prostate cancer cells growth, and Sun2 knockdown promotes the prostate cancer cells growth both in vitro and vivo. Mechanical silencing of, Sun2 promoted fatty acid oxidation (FAO) in prostate cancer, prostate cancer cells growth promoted by Sun2 silencing could be reversed by the FAO inhibitor Etomoxir. Additionally, we also showed that serum amyloid A1 (SAA1) play a vital role in FAO, ATP and cell growth promoted by Sun2 loss in prostate cancer. These results suggest that Loss of Sun2 promoted the prostate cancer progression by regulating FAO.
关键词	prostate cancer fatty acid oxidation Sun2 SAA1 overall survival
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81472398]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000414097100019
出版者	IMPACT JOURNALS LLC
WOS关键词	CELL-PROLIFERATION ; DOWN-REGULATION ; EXPRESSION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/14313
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_陈佳组生命科学与技术学院_硕士生
通讯作者	Chen Jia; Wang Zhong; Xu Bin
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Urol, Shanghai, Peoples R China 2.Second Mil Med Univ, Changhai Hosp, Dept Urol, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Cheng Yajun,Ye Chen,Li Xiaosa,et al. Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation[J]. ONCOTARGET,2017,8(52):89620-89630.
APA	Cheng Yajun.,Ye Chen.,Li Xiaosa.,Wang Xiao.,Chen Jia.,...&Xu Bin.(2017).Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation.ONCOTARGET,8(52),89620-89630.
MLA	Cheng Yajun,et al."Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation".ONCOTARGET 8.52(2017):89620-89630.