CTP synthase forms the cytoophidium in human hepatocellular carcinoma

doi:10.1016/j.yexcr.2017.10.030

	CTP synthase forms the cytoophidium in human hepatocellular carcinoma
	Chang, Chia-Chun 1,2; Jeng, Yung-Ming 3,4; Peng, Min 2; Keppeke, Gerson Dierley 1; Sung, Li-Ying 2,5; Liu, Ji-Long1,6
	2017-12-15
发表期刊	EXPERIMENTAL CELL RESEARCH (IF:3.3[JCR-2023],3.3[5-Year])
ISSN	0014-4827
卷号	361 期号:2 页码:292-299
发表状态	已发表
DOI	10.1016/j.yexcr.2017.10.030
摘要	CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma.
关键词	CTP synthase Cytoophidium Glutamine metabolism Heatshock protein 90 Human hepatocellular carcinoma Nucleotide Protein filamentation Pyrimidine
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology, Taiwan, ROC[104-2313-B-002-035-MY3] ; Ministry of Science and Technology, Taiwan, ROC[106-2917-I-002-043]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000417774300011
出版者	ELSEVIER INC
WOS关键词	SYNTHETASE-ACTIVITY ; HSP90 ; COMPARTMENTATION ; EXPRESSION ; PROTEINS ; REVEALS ; COMPLEX
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/14292
专题	生命科学与技术学院生命科学与技术学院_PI研究组_刘冀珑组
通讯作者	Sung, Li-Ying; Liu, Ji-Long
作者单位	1.Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England 2.Natl Taiwan Univ, Inst Biotechnol, Taipei 106, Taiwan 3.Natl Taiwan Univ Hosp, Dept Pathol, Taipei 10002, Taiwan 4.Natl Taiwan Univ, Grad Inst Pathol, Coll Med, Taipei 10051, Taiwan 5.Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chang, Chia-Chun,Jeng, Yung-Ming,Peng, Min,et al. CTP synthase forms the cytoophidium in human hepatocellular carcinoma[J]. EXPERIMENTAL CELL RESEARCH,2017,361(2):292-299.
APA	Chang, Chia-Chun,Jeng, Yung-Ming,Peng, Min,Keppeke, Gerson Dierley,Sung, Li-Ying,&Liu, Ji-Long.(2017).CTP synthase forms the cytoophidium in human hepatocellular carcinoma.EXPERIMENTAL CELL RESEARCH,361(2),292-299.
MLA	Chang, Chia-Chun,et al."CTP synthase forms the cytoophidium in human hepatocellular carcinoma".EXPERIMENTAL CELL RESEARCH 361.2(2017):292-299.