Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging

doi:10.1038/s41598-017-00725-4

	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
	Gao, Fei1,2 ; Feng, Xiaohua 1; Zhang, Ruochong 1; Liu, Siyu 1; Ding, Ran 1; Kishor, Rahul 1; Zheng, Yuanjin 1
	2017-04-04
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7
发表状态	已发表
DOI	10.1038/s41598-017-00725-4
摘要	Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear effect, which originates from unsatisfied stress and thermal confinements. Being different from conventional short laser pulse illumination, the proposed method utilizes a long square-profile laser pulse to induce dual photoacoustic signals. Without satisfying the stress confinement, the dual photoacoustic signals are generated following the positive and negative edges of the long laser pulse. More interestingly, the first expansion-induced photoacoustic signal exhibits positive waveform due to the initial sharp rising of temperature. On the contrary, the second contraction-induced photoacoustic signal exhibits exactly negative waveform due to the falling of temperature, as well as pulse-width-dependent signal amplitude. An analytical model is derived to describe the generation of the dual photoacoustic pulses, incorporating Gruneisen saturation and thermal diffusion effect, which is experimentally proved. Lastly, an alternate of LDPA technique using quasi-CW laser excitation is also introduced and demonstrated for both super-contrast in vitro and in vivo imaging. Compared with existing nonlinear PA techniques, the proposed LDPA nonlinear effect could enable a much broader range of potential applications.
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000398162600002
出版者	NATURE PUBLISHING GROUP
WOS关键词	MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY ; SPECTROSCOPY ; MICROSCOPY ; LIGHT
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1422
专题	信息科学与技术学院_PI研究组_高飞组
通讯作者	Zheng, Yuanjin
作者单位	1.Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore, Singapore 2.ShanghaiTech Univ, Sch Informat Sci & Technol, Shanghai, Peoples R China
第一作者单位	信息科学与技术学院
推荐引用方式 GB/T 7714	Gao, Fei,Feng, Xiaohua,Zhang, Ruochong,et al. Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging[J]. SCIENTIFIC REPORTS,2017,7.
APA	Gao, Fei.,Feng, Xiaohua.,Zhang, Ruochong.,Liu, Siyu.,Ding, Ran.,...&Zheng, Yuanjin.(2017).Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging.SCIENTIFIC REPORTS,7.
MLA	Gao, Fei,et al."Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging".SCIENTIFIC REPORTS 7(2017).