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Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase | |
Hu, Rongkuan1,2,4,6; Yan, Huan3; Fei, Xiaoyan6; Liu, Haiyang3; Wu, Jiarui1,2,4,5 | |
2017-04-10 | |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 7 |
发表状态 | 已发表 |
DOI | 10.1038/s41598-017-00925-y |
摘要 | AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2C12 myotubes by stimulating glucose transporter-4 (GLUT-4) membraned translocation. Treatment of primary mouse hepatocytes with shizukaol F decreased the expression of phosphoenolpyruvate carboxykinase 2 (PEPCK), glucose-6-phosphatase (G6Pase) and suppressed hepatic gluconeogenesis. Meanwhile, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice. Further studies indicated that shizukaol F modulates glucose metabolism mainly by AMPKa phosphorylation activity. In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits respiratory complex I, which may result in AMPK activation. Our results highlight the potential value of shizukaol F as a possible treatment of metabolic syndrome. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[31130034] ; National Natural Science Foundation of China[31470808] ; National Natural Science Foundation of China[81072543] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000399071500001 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | SKELETAL-MUSCLE ; METFORMIN ; AICAR ; ROSIGLITAZONE ; INCREASE ; GLUCONEOGENESIS ; ADIPOCYTES ; INHIBITION ; EXPRESSION ; OXIDATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1417 |
专题 | 生命科学与技术学院 |
通讯作者 | Liu, Haiyang; Wu, Jiarui |
作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,et al. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase[J]. SCIENTIFIC REPORTS,2017,7. |
APA | Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,Liu, Haiyang,&Wu, Jiarui.(2017).Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase.SCIENTIFIC REPORTS,7. |
MLA | Hu, Rongkuan,et al."Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase".SCIENTIFIC REPORTS 7(2017). |
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