Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity

doi:10.1242/dev.141341

	Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
	Xu, Jiajun 1; Hao, Xue 1; Yin, Meng-Xin 1; Lu, Yi 1; Jin, Yunyun 1; Xu, Jinjin 1; Ge, Ling 1; Wu, Wenqing 1; Ho, Margaret 2; Yang, Yingzi 3; Zhao, Yun1,4 ; Zhang, Lei1,4
	2017-04-15
发表期刊	DEVELOPMENT (IF:3.7[JCR-2023],5.0[5-Year])
ISSN	0950-1991
卷号	144 期号:8 页码:1510-1517
发表状态	已发表
DOI	10.1242/dev.141341
摘要	The Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation.
关键词	Nerfin-1 Medulla neurons Dedifferentiation Notch signaling
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31625017] ; National Natural Science Foundation of China[31530043] ; National Natural Science Foundation of China[31371462]
WOS研究方向	Developmental Biology
WOS类目	Developmental Biology
WOS记录号	WOS:000402175000016
出版者	COMPANY OF BIOLOGISTS LTD
WOS关键词	DROSOPHILA OPTIC LOBE ; REGULATES SELF-RENEWAL ; STEM-CELLS ; TUMOR-SUPPRESSOR ; LARVAL BRAIN ; DIFFERENTIATION ; PROLIFERATION ; LINEAGE ; TRANSCRIPTION ; MELANOGASTER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1411
专题	生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Zhang, Lei
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol,State Key Lab C, Innovat Ctr Cell Signaling Network,CAS Ctr Excell, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China 3.Harvard Sch Dent Med, Dept Dev Biol, Boston, MA 02115 USA 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xu, Jiajun,Hao, Xue,Yin, Meng-Xin,et al. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity[J]. DEVELOPMENT,2017,144(8):1510-1517.
APA	Xu, Jiajun.,Hao, Xue.,Yin, Meng-Xin.,Lu, Yi.,Jin, Yunyun.,...&Zhang, Lei.(2017).Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity.DEVELOPMENT,144(8),1510-1517.
MLA	Xu, Jiajun,et al."Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity".DEVELOPMENT 144.8(2017):1510-1517.