In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles
Li, Rong1; Wu, Guozhong1,2; Cai, Ximing1; Ye, Yin1
2017-05
Source PublicationRADIATION PHYSICS AND CHEMISTRY
ISSN0969-806X
Volume134Pages:27-32
Status已发表
DOI10.1016/j.radphyschem.2017.01.006
AbstractPoly(acrylic acid), poly(sodium styrenesulfonate), and poly(acrylic acid-co-sodium styrenesulfonate) chains were immobilized onto poly(vinyl alcohol) (PVA) particles via a facile gamma-ray simultaneous irradiation induced graft polymerization technique, which were confirmed by the attenuated total reflection Fourier transform infrared spectroscopy and the high swelling ratios of modified PVA particles. The effects of absorbed dose, dose rate, Cu2+ concentration and monomer concentration on the degree of grafting (DG) of PVA particles were investigated to find out a feasible process for preparing polyanionic chains graft-modified PVA particles. The clotting time results illustrated that both PVA-g-PAA and PVA-g-PSSS particles presented excellent anticoagulant activity, and the activated partial thromboplastin time (APTI), prothrombin time (PT) and thrombin time (TT) were effectively prolonged with the increase of DG(AA) and DG(sss), respectively. Furthermore, the anticoagulant activity of PVA-g-PSSS samples was more efficient than that of PVA-g-PAA samples. However, the anticoagulant effect of PVA-g-P(AA-co-SSS) samples was different from that of PVA-g-PAA and PVA-g-PSSS samples, and was similar to that of heparin, mainly elongating the APTT and TT. This might be due to both of them containing the same negative-charged groups. Additionally, the grafted PVA particles were all non hemolytic, showing good blood compatibility.
Keywordgamma-ray simultaneous irradiation induced graft polymerization Poly(vinyl alcohol) Acrylic acid Sodium styrenesulfonate Anticoagulant activity
Indexed BySCI ; EI
Language英语
Funding ProjectNational Natural Science Foundation of China[11605275] ; National Natural Science Foundation of China[11675247]
WOS Research AreaChemistry ; Nuclear Science & Technology ; Physics
WOS SubjectChemistry, Physical ; Nuclear Science & Technology ; Physics, Atomic, Molecular & Chemical
WOS IDWOS:000395607900005
PublisherPERGAMON-ELSEVIER SCIENCE LTD
EI Accession Number20170403286452
EI KeywordsAscorbic acid ; Carboxylic acids ; Chains ; Fourier transform infrared spectroscopy ; Gamma rays ; Grafting (chemical) ; Irradiation ; Organic acids ; Polymerization ; Sodium
EI Classification NumberAlkali Metals:549.1 ; Mechanical Drives:602.1 ; Chemistry:801 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Polymerization:815.2 ; Atomic and Molecular Physics:931.3
WOS KeywordSTYRENE-SULFONATE ; CROSS-LINKING ; HEMOCOMPATIBILITY ; CELLULOSE ; POLYMERS ; HEPARIN ; SURFACE ; BIOCOMPATIBILITY ; SULFATE
Original Document TypeArticle
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1400
Collection物质科学与技术学院_特聘教授组_吴国忠组
Corresponding AuthorYe, Yin
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Li, Rong,Wu, Guozhong,Cai, Ximing,et al. In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles[J]. RADIATION PHYSICS AND CHEMISTRY,2017,134:27-32.
APA Li, Rong,Wu, Guozhong,Cai, Ximing,&Ye, Yin.(2017).In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.RADIATION PHYSICS AND CHEMISTRY,134,27-32.
MLA Li, Rong,et al."In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles".RADIATION PHYSICS AND CHEMISTRY 134(2017):27-32.
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